E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Correlation of vitamin D levels and pain in rheumatoid arthritis

H K S Chawla, Gaurav Kumar Gupta, Hari Om Aggarwal, Girish Sahni, Ashish Kavia.

Abstract
Background: Rheumatoid arthritis (RA) is an autoimmune disease that causes pain, stiffness, swelling, loss of joint function, and a rise in acute-phase reactant levels. Pain causes much discomfort in patients with RA. Disease-Modifying Antirheumatic Drugs, Non-Steroidal Anti-Inflammatory Drugs, and Glucocorticoids are commonly used to treat RA, but these medications alleviate the inflammatory process to improve short- and long-term goals of treatment. Vitamin D has immunomodulatory properties that may be effective in RA patients, suggesting that Vitamin D may have a remedial effect in these patients.

Aims and Objectives: The aim of this study was to evaluate the effectiveness of vitamin D in controlling the inflammatory response thus controlling pain in patients with RA.

Materials and Methods: The study analyzed 96 diagnosed cases of RA presenting to our tertiary care center. The subjects were allocated into two groups one in which Vitamin D was supplemented and other in which placebo was given. Their disease activity was measured and VAS score was analyzed at presentation and 1 month and 3 months of follow-up.

Results: At presentation levels of Vitamin D were inversely correlated with disease activity. Mean VAS score decreased subsequently during the follow up from 3.2 ± 1.7 at presentation to 2.25 ± 1.12 in Vitamin D group and from 4.38 ± 1.79 at presentation to 2.67 ± 1.19 at 3 months follow-up in placebo group, respectively.

Conclusion: Vitamin D supplementation did not statistically significantly improved the VAS score thus requiring the need for further research for the evaluation of Vitamin D supplementation in the treatment of RA.

Key words: Rheumatoid Arthritis; Vitamin D; Disease Severity; Visual Analog Scale


 
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How to Cite this Article
Pubmed Style

Chawla HKS, Gupta GK, Aggarwal HO, Sahni G, Kavia A. Correlation of vitamin D levels and pain in rheumatoid arthritis. Natl J Physiol Pharm Pharmacol. 2022; 12(2): 210-214. doi:10.5455/njppp.2022.12.12452202124122021


Web Style

Chawla HKS, Gupta GK, Aggarwal HO, Sahni G, Kavia A. Correlation of vitamin D levels and pain in rheumatoid arthritis. https://www.njppp.com/?mno=87232 [Access: May 02, 2022]. doi:10.5455/njppp.2022.12.12452202124122021


AMA (American Medical Association) Style

Chawla HKS, Gupta GK, Aggarwal HO, Sahni G, Kavia A. Correlation of vitamin D levels and pain in rheumatoid arthritis. Natl J Physiol Pharm Pharmacol. 2022; 12(2): 210-214. doi:10.5455/njppp.2022.12.12452202124122021



Vancouver/ICMJE Style

Chawla HKS, Gupta GK, Aggarwal HO, Sahni G, Kavia A. Correlation of vitamin D levels and pain in rheumatoid arthritis. Natl J Physiol Pharm Pharmacol. (2022), [cited May 02, 2022]; 12(2): 210-214. doi:10.5455/njppp.2022.12.12452202124122021



Harvard Style

Chawla, H. K. S., Gupta, . G. K., Aggarwal, . H. O., Sahni, . G. & Kavia, . A. (2022) Correlation of vitamin D levels and pain in rheumatoid arthritis. Natl J Physiol Pharm Pharmacol, 12 (2), 210-214. doi:10.5455/njppp.2022.12.12452202124122021



Turabian Style

Chawla, H K S, Gaurav Kumar Gupta, Hari Om Aggarwal, Girish Sahni, and Ashish Kavia. 2022. Correlation of vitamin D levels and pain in rheumatoid arthritis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (2), 210-214. doi:10.5455/njppp.2022.12.12452202124122021



Chicago Style

Chawla, H K S, Gaurav Kumar Gupta, Hari Om Aggarwal, Girish Sahni, and Ashish Kavia. "Correlation of vitamin D levels and pain in rheumatoid arthritis." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 210-214. doi:10.5455/njppp.2022.12.12452202124122021



MLA (The Modern Language Association) Style

Chawla, H K S, Gaurav Kumar Gupta, Hari Om Aggarwal, Girish Sahni, and Ashish Kavia. "Correlation of vitamin D levels and pain in rheumatoid arthritis." National Journal of Physiology, Pharmacy and Pharmacology 12.2 (2022), 210-214. Print. doi:10.5455/njppp.2022.12.12452202124122021



APA (American Psychological Association) Style

Chawla, H. K. S., Gupta, . G. K., Aggarwal, . H. O., Sahni, . G. & Kavia, . A. (2022) Correlation of vitamin D levels and pain in rheumatoid arthritis. National Journal of Physiology, Pharmacy and Pharmacology, 12 (2), 210-214. doi:10.5455/njppp.2022.12.12452202124122021