E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
04 / 09 / 2023

 


Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center

Karthikeyan T M, Veenaa N N, Shivapriya R, Arun Kumar, Umamageswari M S.


Abstract
Background: Diabetes mellitus (DM) is a common metabolic disorder leading to microvascular and macrovascular complications. Chronic inflammation accelerates the development of complications associated with DM. Measurement of inflammatory mediators is not practically feasible. Neutrophil–lymphocyte ratio (NLR) serves as a cheap, reliable, and valid marker for assessing inflammatory activity.

Aims and Objectives: (i) To evaluate the correlation of NLR and microalbuminuria in DM patients; (ii) to evaluate the correlation of NLR with HbA1c; and (iii) to evaluate the correlation of platelet count with microalbuminuria.

Materials and Methods: One hundred patients of either sex with DM were evaluated for microalbuminuria, NLR, HbA1c, and platelet count after obtaining institutional human ethics committee clearance. NLR was evaluated for correlation with microalbuminuria and HbA1c. Platelet count was also evaluated for correlation with microalbuminuria.

Results: Mean NLR of male patient was 2.1 and female was 2.33. The mean microalbuminuria level in male patient was 527.03 mcg/mg of creatinine and female was 215.36 mcg/mg of creatinine. There was a moderate degree of correlation of microalbuminuria with increased NLR. The study showed a strong correlation between NLR, microalbuminuria, HbA1c, and platelet count.

Conclusion: NLR has a strong correlation with microalbuminuria and could be used to assess the onset and progression of diabetic nephropathy.

Key words: Neutrophil–lymphocyte Ratio; Microalbuminuria; Diabetes Mellitus; HbA1c


 
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How to Cite this Article
Pubmed Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2024; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023


Web Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. https://www.njppp.com/?mno=163438 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.08381202316082023


AMA (American Medical Association) Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2024; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023



Vancouver/ICMJE Style

M KT, N VN, R S, Kumar A, S UM. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol. (2024), [cited March 14, 2024]; 14(3): 473-479. doi:10.5455/njppp.2023.13.08381202316082023



Harvard Style

M, K. T., N, . V. N., R, . S., Kumar, . A. & S, . U. M. (2024) Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. Natl J Physiol Pharm Pharmacol, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023



Turabian Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. 2024. Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023



Chicago Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. "Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 473-479. doi:10.5455/njppp.2023.13.08381202316082023



MLA (The Modern Language Association) Style

M, Karthikeyan T, Veenaa N N, Shivapriya R, Arun Kumar, and Umamageswari M S. "Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 14.3 (2024), 473-479. Print. doi:10.5455/njppp.2023.13.08381202316082023



APA (American Psychological Association) Style

M, K. T., N, . V. N., R, . S., Kumar, . A. & S, . U. M. (2024) Neutrophil–lymphocyte ratio as a diagnostic marker for predicting early-stage diabetic nephropathy in patients attending a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 14 (3), 473-479. doi:10.5455/njppp.2023.13.08381202316082023