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Original Research

Online Publishing Date:
23 / 08 / 2022

 


Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats

Vijai Sundar E, Sandeep V M, Beyaril Chitra C, Sarath Babu K, Leo David P.


Abstract
Background: Arthritis is a leading cause of physical disability and impaired quality of life. At present, symptomatic treatment is available for arthritis. According to literature, apigenin possess anti-inflammatory activity.

Aims and Objectives: The present study aimed to screen the anti-inflammatory activity of Apigenin in freund’s induced arthritis in Wistar albino rats.

Materials and Methods: A total 30 rats were selected and divided into five groups each of six animals. Group – I (Normal saline), Group – II (Freund’s adjuvant (0.1 ml of 0.5%), Group – III (Dexamethasone 0.1 mg/kg), Group – IV (Apigenin 50 mg/kg), and Group – V (Apigenin 100 mg/kg) doses were administered to their respective groups for 28 days. X-ray was taken on 28th day and animals were sacrificed and affected paw used for histopathological examination.

Results: Group – II rats showed inflammation, thickness, fibro, and fatty changes in joint compared to Group – I X-ray and histopathological examination. Groups – III and V rats showed reduction inflammation, thickness, and fatty changes compared to Group – II. Group – IV showed lesser effect compared Group – V.

Conclusion: Apigenin administration significantly prevent the Freund’s induced radiological and histopathological changes in rats.

Key words: Apigenin; Freund’s; Dexamethasone; Rat Paw; Histopathology; X-ray


 
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How to Cite this Article
Pubmed Style

E VS, M SV, C BC, K SB, P LD. Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022

Web Style

E VS, M SV, C BC, K SB, P LD. Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. https://www.njppp.com/?mno=89451 [Access: March 14, 2024]. doi:10.5455/njppp.2022.12.08389202216082022

AMA (American Medical Association) Style

E VS, M SV, C BC, K SB, P LD. Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


Vancouver/ICMJE Style

E VS, M SV, C BC, K SB, P LD. Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. Natl J Physiol Pharm Pharmacol. (2022), [cited March 14, 2024]; 12(10): 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


Harvard Style

E, V. S., M, . S. V., C, . B. C., K, . S. B. & P, . L. D. (2022) Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. Natl J Physiol Pharm Pharmacol, 12 (10), 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


Turabian Style

E, Vijai Sundar, Sandeep V M, Beyaril Chitra C, Sarath Babu K, and Leo David P. 2022. Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


Chicago Style

E, Vijai Sundar, Sandeep V M, Beyaril Chitra C, Sarath Babu K, and Leo David P. "Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


MLA (The Modern Language Association) Style

E, Vijai Sundar, Sandeep V M, Beyaril Chitra C, Sarath Babu K, and Leo David P. "Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats." National Journal of Physiology, Pharmacy and Pharmacology 12.10 (2022), 1614-1618. Print. doi:10.5455/njppp.2022.12.08389202216082022


APA (American Psychological Association) Style

E, V. S., M, . S. V., C, . B. C., K, . S. B. & P, . L. D. (2022) Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1614-1618. doi:10.5455/njppp.2022.12.08389202216082022


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