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Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain.

Abstract
Background: Many trace elements in the biological system, including boron, are involved in various vital processes related to health and diseases. Boron has been proved to have a role in decreasing inflammatory pain, joint stiffness, and other disabling symptoms associated with osteoarthritis (OA).

Aims and Objective: To evaluate the relationship between serum concentrations of boron with inflammatory markers, disease duration, and severity in patients with knee OA.

Materials and Methods: A total of 43 patients with knee OA were clinically evaluated and serum boron concentrations were measured in addition to erythrocyte sedimentation rate (ESR) and total white blood cell (WBC) count; the results were compared with that of healthy controls. Boron levels were correlated with ESR, WBC, disease duration, and severity.

Result: Serum boron levels were significantly lower in patients compared with controls, and found to be significantly correlated with disease duration and severity. No correlation was reported between boron and the inflammatory markers.

Conclusion: Serum boron levels were significantly lower in patients with knee OA, and negatively correlated with the duration and severity of the disease.

Key words: Knee OA; Serum Boron; Disease Severity; ESR; WBC Count


 
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REFERENCES
1. Roush JK, McLaughlin RM, Radlinsky MG. Understanding the pathophysiology of osteoarthritis. Vet Med. 2002;97:108-17.
2. Haskin CL, Milam SB, Cameron IL. Pathogenesis of degenerative joint disease in the human temporomandibular joint. Crit Rev Oral Biol Med. 1995;6:248-77. [DOI via Crossref]    [Pubmed]   
3. Pasha Q, Malik SA, Shaheen N, Shah MH. Investigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls. Clin Chim Acta. 2010;411:531-9. [DOI via Crossref]    [Pubmed]   
4. Lukaski HC. Vitamin and mineral status: effects on physical performance. Nutrition. 2004;20:632-44. [DOI via Crossref]    [Pubmed]   
5. Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr. 2003;43:219-31. [DOI via Crossref]    [Pubmed]   
6. Hunt CD. Dietary boron: an overview of the evidence for its role in immune function. J Trace Elem Exp Med. 2003;16:291-306. [DOI via Crossref]   
7. Nielsen F. Update on human health effects of boron. J Trace Elem Med Biol. 2014;28:383-7. [DOI via Crossref]    [Pubmed]   
8. Hunt CD. Dietary boron: progress in establishing essential roles in human physiology. J Trace Elem Med Biol. 2012;26:157-60. [DOI via Crossref]    [Pubmed]   
9. Scorei R, Ciubar R, Iancu C, Mitran V, Cimpean A, Iordachescu D. In vitro effects of calcium fructoborate on fMLP stimulated human neutrophil granulocytes. Biol Trace Elem Res. 2007;118: 27-37. [DOI via Crossref]    [Pubmed]   
10. Scorei RI, Ciofrangeanu C, Ion R, Cimpean A, Galateanu B, Mitran V, et al. In vitro effects of calcium fructoborate upon production of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. Biol Trace Elem Res. 2010;135:334-44. [DOI via Crossref]    [Pubmed]   
11. Miljkovic D, Scorei IR, Cimpoiasu VM, Scorei ID. Calcium fructoborate: plant-based dietary boron for human nutrition. J Diet Suppl. 2009;6:211-26. [DOI via Crossref]    [Pubmed]   
12. Al-Rawi Z, Gorial FI, Al-Shammary WA, Muhsin F, Al-Naaimi AS, Kareem S. Serum boron concentration in rheumatoid arthritis: correlation with disease activity, functional class, and rheumatoid factor. J Exp Integr Med. 2013;3(1):9-15.
13. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Med Biol. 2010;24:243-50. [DOI via Crossref]    [Pubmed]   
14. Scorei R, Mirrut P, Petrisor I, Scorei I. A double blind, placebo controlled study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle aged people with primary osteoarthritis. Biol Trace Elem Res. 2011;144:253-63. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
15. Anonymous. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43(9):1905-15.
16. Ahlback S. Osteoarthrosis of the knee: a radiographic investigation. Acta Radiol Stockholm. 1968;(Suppl. 277):7-72.
17. Spector T, Hart D. How serious is knee osteoarthritis? Ann Rheum Dis. 1992;51:1105-6.
18. Leibovitz A, Lubart E, Wainstein J, Dror Y, Segal R. Serum trace elements in elderly frail patients with oropharyngeal dysphagia. J Nutr Sci Vitaminol (Tokyo). 2009;55(5):407-11. [DOI via Crossref]   
19. Nielsen FH, Meacham SL. Growing evidence for human health benefits of boron. J Evid Based Complement Alternat Med. 2011;16:169-80. [DOI via Crossref]   
20. Sandstead HH, Penland JG, Alcock NW, Dayal HH, Chen XC, Li JS, et al. Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children.
21. Peng X, Lingxia Z, Schrauzer GN, Xiong G. Selenium, boron, and Am J Clin Nutr. 1998;68:470S-5S. germanium deficiency in the etiology of Keshan-Beck disease. Biol Trace Elem Res. 2000;77:193-7. [DOI via Crossref]   
22. Fracp RLT, Rennie GC, Newnham RE. Boron and arthritis: the results of a double-blind pilot study. J Nutr Med. 1990;1:127-32.
23. Gallardo-Williams MT, Chapin RE, King PE, Moser GJ, Goldsworthy TL, Morrison JP, et al. Boron supplementation inhibits growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Toxicol Pathol. 2004;32:73-8. [DOI via Crossref]    [Pubmed]   
24. Hunt CD, Idso JP. Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress. J Trace Elem Exp Med. 1999;12:221-33. [DOI via Crossref]   
25. Havercroft JM, Ward NI. Boron and other elements in relation to rheumatoid arthritis In: Momcilovic B (Ed.), Trace Elements in Man and Animals 7. Zagreb, Croatia: IMI, 1991. pp. 8.2-8.3.
26. Reyes-Izquierdo T, Nemzer B, Gonzalez AE, Zhou Q, Argumedo R, Shu C. Short-term intake of calcium fructoborate improves WOMAC and McGill scores and beneficially modulates biomarkers associated with knee osteoarthritis: a pilot clinical double-blinded placebo-controlled study. Am J Biomed Sci. 2012;4(2):111-22. [DOI via Crossref]   
27. Scorei ID, Scorei RI. Calcium fructoborate helps control inflammation associated with diminished bone health. Biol Trace Elem Res. 2013;155(3):315-21. [DOI via Crossref]    [Pubmed]   
28. Mohammed-Ameen HN, Hussain SA, Ahmed ZA, Aziz TA. Antiinflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation. Int J Basic Clin Pharmacol. 2015;4:701-7. [DOI via Crossref]   

How to Cite this Article
Pubmed Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. Natl J Physiol Pharm Pharmacol. 2016; 6(1): 27-31. doi:10.5455/njppp.2015.5.0809201576

Web Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. https://www.njppp.com/?mno=201115 [Access: August 03, 2022]. doi:10.5455/njppp.2015.5.0809201576

AMA (American Medical Association) Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. Natl J Physiol Pharm Pharmacol. 2016; 6(1): 27-31. doi:10.5455/njppp.2015.5.0809201576


Vancouver/ICMJE Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. Natl J Physiol Pharm Pharmacol. (2016), [cited August 03, 2022]; 6(1): 27-31. doi:10.5455/njppp.2015.5.0809201576


Harvard Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain (2016) Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. Natl J Physiol Pharm Pharmacol, 6 (1), 27-31. doi:10.5455/njppp.2015.5.0809201576


Turabian Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. 2016. Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. National Journal of Physiology, Pharmacy and Pharmacology, 6 (1), 27-31. doi:10.5455/njppp.2015.5.0809201576


Chicago Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. "Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 27-31. doi:10.5455/njppp.2015.5.0809201576


MLA (The Modern Language Association) Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain. "Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city." National Journal of Physiology, Pharmacy and Pharmacology 6.1 (2016), 27-31. Print. doi:10.5455/njppp.2015.5.0809201576


APA (American Psychological Association) Style

Naza Mohammad Ali Mahmood, Omer Rafiq Barawi, Saad Abdulrahman Hussain (2016) Relationship between serum concentrations of boron and inflammatory markers, disease duration, and severity of patients with knee osteoarthritis in Sulaimani city. National Journal of Physiology, Pharmacy and Pharmacology, 6 (1), 27-31. doi:10.5455/njppp.2015.5.0809201576


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