Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model

Pratik Kumar Chatterjee; Vinodini Nithyanandamadom Anantharaya; Anish Singhal; Poulomi Chatterjee; Rashmi Kapu Shiva; Roopashree Mallya

doi:10.5455/njppp.2016.6.2709201591

2024, Vol: 14, Issue: 4

14 / 4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
27 / 02 / 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122

doi: 10.5455/njppp.2016.6.2709201591

Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya.

Abstract
Background: Cadmium (Cd), an environmental metallic toxicant with varying degrees of toxicity, exists in different oxidational or transitional states and causes various blood disorders. Cadmium (Cd) is known to affect various organs on both acute and chronic exposures. Studies have revealed that the most important tissue in body in which metabolic alterations are mainly reproduced is the blood. Moringa oleifera, originally from India, has been scientifically assessed for various medicinal applications.

Aims and Objective: To examine the effect of M. oleifera aqueous extract taken from the leaf on total leukocyte count including its differentials (neutrophils and lymphocytes) in cadmium-treated rats.

Materials and Methods: Twenty-four adult Wistar Albino rats, weighing between 180 and 200 g were broadly divided into four groups, six animals in each group, with group I being the control. Group IV was pretreated with the extract and then cadmium chloride orally for 1 day. Data were presented as mean ± SD and p ≤ 0.05 considered significant.

Result: The results portrayed that pretreatment with Moringa leaf extract, 100 mg/kg/bw, earlier to the cadmium administration exhibited a significant increase (p ≤ 0.001) in the total leukocyte count including its differentials in comparison with the cadmium-exposed group, whereas the total WBC count was significantly decreased in group III in comparison with groups I and II. This study depicts a marked increase in the total leukocyte (T-WBC) count and its differentials in the animals pretreated with Moringa oleifera leaf extract, before the infusion of cadmium could be an indication that M. oleifera offers protection against damage to hematological parameters induced by cadmium.

Conclusion: Therefore, our study suggests that aqueous leaf extract of M. oleifera enhances the immune mechanisms to fight back foreign substances when exposed to cadmium toxicity.

Key words: Cadmium; Blood Disorders; Moringa oleifera; Leukocyte Count; Immune Mechanisms

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Pratik Kumar Chatterjee Articles by Vinodini Nithyanandamadom Anantharaya Articles by Anish Singhal Articles by Poulomi Chatterjee Articles by Rashmi Kapu Shiva Articles by Roopashree Mallya
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Web Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. https://www.njppp.com/?mno=202157 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.2709201591

AMA (American Medical Association) Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Vancouver/ICMJE Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol. (2016), [cited March 14, 2024]; 6(2): 119-122. doi:10.5455/njppp.2016.6.2709201591

Harvard Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya (2016) Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. Natl J Physiol Pharm Pharmacol, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

Turabian Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. 2016. Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

Chicago Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. "Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 119-122. doi:10.5455/njppp.2016.6.2709201591

MLA (The Modern Language Association) Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya. "Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 119-122. Print. doi:10.5455/njppp.2016.6.2709201591

APA (American Psychological Association) Style

Pratik Kumar Chatterjee, Vinodini Nithyanandamadom Anantharaya, Anish Singhal, Poulomi Chatterjee, Rashmi Kapu Shiva, Roopashree Mallya (2016) Moringa oleifera aqueous leaf extract: role on total leucocyte count and its differentials in cadmium toxicity in adult Wistar Albino rat model. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 119-122. doi:10.5455/njppp.2016.6.2709201591

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272