E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan.

Cited by (8)

Abstract
Background: Liver cancer is a deadly disease and devastating public health problem globally. Natural plant products with potent growth inhibition, and apoptosis induction properties are extensively being investigated for their cancer-preventive potential. Allium ascalonicum, being an important part of the diet across various countries, possesses numerous therapeutic effects and health-enhancing properties such as cancer prevention.

Aims and Objective: To investigate anticancer activity of dry and fresh A. ascalonicum.

Materials and Methods: The organic (ethanol) extracts of dry and fresh shallot bulb (A. ascalonicum) were prepared and tested for in vitro anticancer efficacy on liver cancer cell line HepG2 by MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Results: The results showed that both dry and fresh shallot extracts have anticancer potential with inhibitory concentration (IC50) of 50 µg/mL.

Conclusion: The plant investigated possesses remarkable anticancer activity. Further studies are essential for the isolation of lead molecules from the plant to treat liver cancer.

Key words: Allium ascalonicum; HepG2 Cell Line; MTT Assay; Anticancer Activity


 
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How to Cite this Article
Pubmed Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112


Web Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. https://www.njppp.com/?mno=214626 [Access: June 01, 2022]. doi:10.5455/njppp.2016.6.08012016112


AMA (American Medical Association) Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112



Vancouver/ICMJE Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. (2016), [cited June 01, 2022]; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112



Harvard Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan (2016) Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112



Turabian Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. 2016. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112



Chicago Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. "Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 196-199. doi:10.5455/njppp.2016.6.08012016112



MLA (The Modern Language Association) Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan. "Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 196-199. Print. doi:10.5455/njppp.2016.6.08012016112



APA (American Psychological Association) Style

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan (2016) Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112