Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats

Shirish Joshi; Urmila Thatte

doi:10.5455/njppp.2012.2.172-178

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Natl J Physiol Pharm Pharmacol. 2012; 2(2): 172-178

doi: 10.5455/njppp.2012.2.172-178

Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats

Shirish Joshi, Urmila Thatte.

Cited by (2)

Abstract
Background: Most of the currently available therapies for peptic ulcer disease have their own limitations and an ideal therapeutic agent is not yet available in the market.Hence,we decided to explore the cytoprotective potential of Indian Medicinal Plants namely Phyllanthus emblica and Asparagus racemosus along with ranitidine as a positive control in various animal models.

Aims & Objective: To evaluate the cytoprotective effect of the extracts of Phyllanthus emblica (PE) and Asparagus racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats.

Materials and Methods: Cold immobilization stress, ethanol (99.9%), aspirin were the experimental models selected for inducing gastric erosions and ulcerations. Ulcer index , erosions, oedema, congestion and inflammation were the parameters studied for assessing gastric damage whereas carrageenininduced rat paw oedema model was used to induce inflammation.Ranitidine was used as a positive control.

Results: The two drugs chosen for the study namely Phyllanthus emblica and Asparagus racemosus prevented gastric damage significantly in the ethanol group (p<0.05) and cold stress group (p<0.05). In the aspirin group, erosions, oedema, congestion and inflammation were remarkably reduced by PE cold water extract (PECWE) and PE hot water extract (PEHWE) and in the AR treated groups when compared with the control group. PECWE and PEHWE showed significant anti-inflammatory activity (p<0.05) comparable to aspirin thereby proving their role in inflammatory disorders. In our study, AR also showed a significant protection (p<0.05) against ethanol, cold stress and aspirin group.

Conclusion: The present study supports that ethanol, cold simmobilization stress and aspirin induce gastritis, gastric erosions and ulcerations and Phyllanthus emblica and Asparagus racemosus have significant potential as prominent cytoprotectants against these toxic effects.

Key words: Ulcer Index, Inflammation, Paw Oedema

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REFERENCES

1. Silen W. What is cytoprotection of the gastric mucosa? Gastroenterology 1988; 94 : 232-5.
[Pubmed]

2. Kauffman G. Aspirin induced gastric mucosal injury: lessons learned from animal models. Gastroenterology 1989;96:606-614.
[Pubmed]

3. Oates PJ, Hakkinen JP. Studies on mechanisms of ethanol induced gastric damage in rats. Gastroenterology 1988;85: 313-317.

4. Tepperman BL, Jacobson ED. Circulatory factoring gastric ulcers. In : Brooks FP, ed. Peptic Ulcers. Contemporary issues in Gastroenterology. New York : Churchil Livingston. Inc. 1985; 261-78.

5. Parmar NS, Tariq M, Ageel AM. Gastric cytoprotection : A critical appraisal of the concept, methodology, implications, mechanisms and future research prospects. Agents and actions 1987;22:114-22.
http://dx.doi.org/10.1007/BF01968826
[Pubmed]

6. Asmawi MZ, Kankaanranta H, Moilanen E, Vapaatalo H. Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. Journal of Pharmacy and Pharmacology 1993;45:581–584.
http://dx.doi.org/10.1111/j.2042-7158.1993.tb05605.x
[Pubmed]

7. Rao MRR, Siddiqui HH. Pharmacological studies on Emblica Officinalis Gaertn. Indian J Exptl Biol 1964;2:29-34.

8. Dahanukar SA, Thatte UM. Rasayan concept of Ayurveda, Myth or reality an experimental study. Ind Practitioner 1988; 41: 245-252.

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How to Cite this Article

Pubmed Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178

Web Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. https://www.njppp.com/?mno=23766 [Access: May 02, 2022]. doi:10.5455/njppp.2012.2.172-178

AMA (American Medical Association) Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. 2012; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178

Vancouver/ICMJE Style

Shirish Joshi, Urmila Thatte. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol. (2012), [cited May 02, 2022]; 2(2): 172-178. doi:10.5455/njppp.2012.2.172-178

Harvard Style

Shirish Joshi, Urmila Thatte (2012) Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. Natl J Physiol Pharm Pharmacol, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178

Turabian Style

Shirish Joshi, Urmila Thatte. 2012. Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178

Chicago Style

Shirish Joshi, Urmila Thatte. "Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats." National Journal of Physiology, Pharmacy and Pharmacology 2 (2012), 172-178. doi:10.5455/njppp.2012.2.172-178

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Shirish Joshi, Urmila Thatte (2012) Pharmacological evaluation of cytoprotective potential of Phyllanthus Emblica (PE) and Asparagus Racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (2), 172-178. doi:10.5455/njppp.2012.2.172-178



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