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Original Research 


Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy

Karan Srivastava, Afroz Abidi, Fardan Qadeer, Fariha Fatima, Roohana Hasan, Darakhshan Rizvi, Anupriya Thadani.

Abstract
Background: History of epilepsy is intertwined with the chronicles of humankind, with millions of people worldwide living with epilepsy, still the current available antiepileptic drugs (AEDs) only suppress seizures without correcting the natural course of epilepsy. Growing limitations of available AEDs have motivated this study to divert our attention towards other safe and natural resources available for the treatment of epilepsy.

Aim and Objective: This study aims to investigate the antiepileptic and cognition-enhancing effects of Citrus aurantium (CA) in a mouse model of pentylenetetrazole (PTZ)-induced generalized tonic–clonic seizures.

Materials and Methods: Kindling was induced by administering 35 mg/kg PTZ to 6-month-old Swiss albino mice for 28 days. Mice were divided into following groups: PTZ control group; CA peel extract group, and Valproic acid (VA) group. The methods used for validating the antiepileptic and cognition-enhancing effects were Behavioral seizure evaluation and Cook’s pole climbing apparatus.

Results: Acute treatment with CA effectively attenuated the seizures induced by PTZ. The antiepileptic and cognition-enhancing effects of CA peel extract were comparable with the standard treatment, that is, VA.

Conclusion: CA showed remarkable antiepileptic and memory-enhancing effects in PTZ-induced seizures and the effects were comparable to VA.

Key words: Epilepsy; Citrus aurantium; Pentylenetetrazole; Behavioral seizure evaluation; Cook’s pole climbing apparatus


 
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How to Cite this Article
Pubmed Style

Srivastava K, Abidi A, Qadeer F, Fatima F, Hasan R, Rizvi D, Thadani A. Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021


Web Style

Srivastava K, Abidi A, Qadeer F, Fatima F, Hasan R, Rizvi D, Thadani A. Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. http://www.njppp.com/?mno=89423 [Access: September 02, 2021]. doi:10.5455/njppp.2021.11.06210202129062021


AMA (American Medical Association) Style

Srivastava K, Abidi A, Qadeer F, Fatima F, Hasan R, Rizvi D, Thadani A. Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021



Vancouver/ICMJE Style

Srivastava K, Abidi A, Qadeer F, Fatima F, Hasan R, Rizvi D, Thadani A. Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021



Harvard Style

Srivastava, K., Abidi, . A., Qadeer, . F., Fatima, . F., Hasan, . R., Rizvi, . D. & Thadani, . A. (2021) Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021



Turabian Style

Srivastava, Karan, Afroz Abidi, Fardan Qadeer, Fariha Fatima, Roohana Hasan, Darakhshan Rizvi, and Anupriya Thadani. 2021. Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021



Chicago Style

Srivastava, Karan, Afroz Abidi, Fardan Qadeer, Fariha Fatima, Roohana Hasan, Darakhshan Rizvi, and Anupriya Thadani. "Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy." doi:10.5455/njppp.2021.11.06210202129062021



MLA (The Modern Language Association) Style

Srivastava, Karan, Afroz Abidi, Fardan Qadeer, Fariha Fatima, Roohana Hasan, Darakhshan Rizvi, and Anupriya Thadani. "Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy." doi:10.5455/njppp.2021.11.06210202129062021



APA (American Psychological Association) Style

Srivastava, K., Abidi, . A., Qadeer, . F., Fatima, . F., Hasan, . R., Rizvi, . D. & Thadani, . A. (2021) Antiepileptic and cognition-enhancing effects of Citrus aurantium peel extract in animal model of epilepsy. doi:10.5455/njppp.2021.11.06210202129062021