E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers

Pavithra Vyshnavi Yogisparan, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, Jeevithan Shanmugam.

Abstract
Background: Gastrointestinal (GI) autonomic neuropathy and reflux esophagitis are common in chronic diabetics. To gauge the adequacy of peristalsis, high-resolution esophageal manometry is considered as a reliable test.

Aim and Objective: To compare the GI symptoms and high-resolution manometry parameters between type II diabetes patients and normal volunteers.

Materials and Methods: This comparative study was conducted on 35 known type II diabetes mellitus patients (hemoglobin A1c [HbA1c] levels ≥6.5%) and 35 normal volunteers between the age group of 35 and 70 years. Sociodemographic details, drug history, disease duration, and GI symptoms were elicited among the study participants. HbA1c and High-resolution manometry were measured for all the participants.

Results: The frequency of epigastric pain (31.48%), heartburn (34.28%), pharyngeal irritation (31.43%), and loose stools (37.14%) were significantly higher in the diabetics. Significant difference (P < 0.05) was observed in mean basal expiratory pressure (MBEP) and mean basal inspiratory pressure (MBIP) values between diabetics and controls. There was a positive significant correlation between esophagogastric junction contractile integral and MBIP (r = 0.557), MBEP (r = 0.583), Median Integrated Relaxation pressure (r = 0.410).

Conclusion: Hyperglycaemia seems to be an independent risk factor for gastroesophageal reflux disease (GERD). Obesity significantly increments the occurrence of GERD in diabetics. Strict adherence to preventive measures such as weight reduction, diet management, glycaemic control will have a great impact on the occurrence of GERD in diabetics.

Key words: High-resolution Manometry; Hemoglobin A1c; Type 2 Diabetes Mellitus; Gastrointestinal Symptoms


 
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How to Cite this Article
Pubmed Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021


Web Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. http://www.njppp.com/?mno=99226 [Access: November 30, 2021]. doi:10.5455/njppp.2022.12.07258202106082021


AMA (American Medical Association) Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021



Vancouver/ICMJE Style

Yogisparan PV, Ramanathan R, Jayabal M, Selvaraj V, Shanmugam J. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021



Harvard Style

Yogisparan, P. V., Ramanathan, . R., Jayabal, . M., Selvaraj, . V. & Shanmugam, . J. (2022) Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021



Turabian Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. 2022. Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021



Chicago Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. "Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers." doi:10.5455/njppp.2022.12.07258202106082021



MLA (The Modern Language Association) Style

Yogisparan, Pavithra Vyshnavi, Rashmi Ramanathan, Mohan Jayabal, Vinothkumar Selvaraj, and Jeevithan Shanmugam. "Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers." doi:10.5455/njppp.2022.12.07258202106082021



APA (American Psychological Association) Style

Yogisparan, P. V., Ramanathan, . R., Jayabal, . M., Selvaraj, . V. & Shanmugam, . J. (2022) Comparison of high-resolution manometry parameters among type II diabetes patients and normal volunteers. doi:10.5455/njppp.2022.12.07258202106082021