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Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study

Vijay Praveen S, Karthik Munagala, Narayana Mood, Grace Swarupa Charles Baddam.

Abstract
Background: Otomycosis is a common condition of the external auditory canal. Aspergillus species and candida species are common causative agents for otomycosis. Clotrimazole is effective in controlling candida species than Aspergillus species. The povidone-iodine is a routinely used antiseptic solution in surgical care.

Aims and Objectives: To assess the efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis.

Materials and Methods: This prospective randomized study recruited 128 cases of both genders. The study participants were randomly divided into two groups. Group 1 received 7.5% povidone-iodine and group 2 received clotrimazole (1%). After removal of otomycotic debris, the study cases were randomly administered with study drugs three drops once a day. All the cases were strictly advised to adhere to the treatment procedure not <2 weeks. Descriptive statistics and Chi-square test was used to test the significance of qualitative data by SPSS 16.0. The P < 0.005 was considered as statistically significant.

Results: After 14 days treatment, 1% clotrimazole group, showed continuous ear discharge (6.25%), pruritus (3.12%), tinnitus (3.12%), otalgia (1.56%), and deafness (1.56%), which was higher than 7.5% povidone-iodine group. Aspergillus niger (1 case) and Aspergillus flavus (2 cases) isolates were observed in 1% clotrimazole group. Good treatment response after the 5th day was seen in 15.62% and 18.75% cases, after the 9th day in 45.31% and 48.43%, and after the 14th day in 87.5% and 75% in 7.5% povidone-iodine and 1% clotrimazole groups, respectively.

Conclusion: The cases treated with 7.5% povidone-iodine were showed comparatively less bacterial and fungal isolates and less clinical signs and symptoms than cases treated with 1% clotrimazole after 2 weeks of treatment follow-up.

Key words: Otomycosis; Anti-fungal Drugs; Efficacy; Aspergillus Species; Candida Species


 
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How to Cite this Article
Pubmed Style

S VP, Munagala K, Mood N, Baddam GSC. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. Natl J Physiol Pharm Pharmacol. Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021


Web Style

S VP, Munagala K, Mood N, Baddam GSC. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. https://www.njppp.com/?mno=87575 [Access: May 03, 2022]. doi:10.5455/njppp.2022.12.12451202124122021


AMA (American Medical Association) Style

S VP, Munagala K, Mood N, Baddam GSC. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. Natl J Physiol Pharm Pharmacol. Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021



Vancouver/ICMJE Style

S VP, Munagala K, Mood N, Baddam GSC. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. Natl J Physiol Pharm Pharmacol, [cited May 03, 2022]; Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021



Harvard Style

S, V. P., Munagala, . K., Mood, . N. & Baddam, . G. S. C. (2022) Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. Natl J Physiol Pharm Pharmacol, Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021



Turabian Style

S, Vijay Praveen, Karthik Munagala, Narayana Mood, and Grace Swarupa Charles Baddam. 2022. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021



Chicago Style

S, Vijay Praveen, Karthik Munagala, Narayana Mood, and Grace Swarupa Charles Baddam. "Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study." National Journal of Physiology, Pharmacy and Pharmacology Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021



MLA (The Modern Language Association) Style

S, Vijay Praveen, Karthik Munagala, Narayana Mood, and Grace Swarupa Charles Baddam. "Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study." National Journal of Physiology, Pharmacy and Pharmacology Online First: 30 Dec, 2021. Web. 03 May 2022 doi:10.5455/njppp.2022.12.12451202124122021



APA (American Psychological Association) Style

S, V. P., Munagala, . K., Mood, . N. & Baddam, . G. S. C. (2022) Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 30 Dec, 2021. doi:10.5455/njppp.2022.12.12451202124122021