Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients

Anita Gupta; Samir Kumar Singh; Jai Singh Yadav; Hanjabam Barun Sharma; Anandita Chakravartty

doi:10.5455/njppp.2023.13.07334202304082023

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Online Publishing Date:
17 / 08 / 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1917-1922

doi: 10.5455/njppp.2023.13.07334202304082023

Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients

Anita Gupta, Samir Kumar Singh, Jai Singh Yadav, Hanjabam Barun Sharma, Anandita Chakravartty.

Abstract
Background: Depression, a serious mental health issue, linked to disruption in mood and cognitive abilities. One of the most crucial elements in the diagnosis and treatment of depression is its severity. Few researches have been conducted to determine the severity of depression on the brainstem and cognitive functioning. Therefore, this study focuses on evaluating brainstem auditory evoked potentials (BAEPs) and event-related potential (P300) parameters among depressive patients regarding severity levels (mild, moderate, and severe).

Aims and Objective: The study aims to assess BAEPs and ERP (P300) parameters among different severity levels (mild, moderate, and severe) of depressive patients and compare the results.

Materials and Methods: This cross-sectional study included 55 depressive patients divided into three groups fulfilling the diagnostic criteria of the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) for major depressive disorder (MDD). The severity of depression was measured by the Hamilton Depression Rating Scale (HDRS). The BAEPs and ERP (P300) were recorded using NeuroStim-NS 2 and auditory oddball paradigm, respectively. Data were analyzed by one-way ANOVA followed by post hoc tests. P < 0.05 was considered statistically significant.

Results: A significant difference was found among three groups of depression severity in BAEPs, wave I for the right ear and IPL I-III for the left ear. P300 wave latency was found to be significant between mild and moderate, and also between moderate and severe groups.

Conclusion: The reported differences in BAEPs and ERP P300 latencies can be attributed to the delay in auditory processing of depressive individuals.

Key words: Depression; Severity; Brainstem Auditory Evoked Potentials; Event-Related Potentials; Cognition

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How to Cite this Article

Pubmed Style

Gupta A, Singh SK, Yadav JS, Sharma HB, Chakravartty A. Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

Web Style

Gupta A, Singh SK, Yadav JS, Sharma HB, Chakravartty A. Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. https://www.njppp.com/?mno=159471 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.07334202304082023

AMA (American Medical Association) Style

Gupta A, Singh SK, Yadav JS, Sharma HB, Chakravartty A. Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

Vancouver/ICMJE Style

Gupta A, Singh SK, Yadav JS, Sharma HB, Chakravartty A. Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(9): 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

Harvard Style

Gupta, A., Singh, . S. K., Yadav, . J. S., Sharma, . H. B. & Chakravartty, . A. (2023) Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. Natl J Physiol Pharm Pharmacol, 13 (9), 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

Turabian Style

Gupta, Anita, Samir Kumar Singh, Jai Singh Yadav, Hanjabam Barun Sharma, and Anandita Chakravartty. 2023. Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

Chicago Style

Gupta, Anita, Samir Kumar Singh, Jai Singh Yadav, Hanjabam Barun Sharma, and Anandita Chakravartty. "Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

MLA (The Modern Language Association) Style

Gupta, Anita, Samir Kumar Singh, Jai Singh Yadav, Hanjabam Barun Sharma, and Anandita Chakravartty. "Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients." National Journal of Physiology, Pharmacy and Pharmacology 13.9 (2023), 1917-1922. Print. doi:10.5455/njppp.2023.13.07334202304082023

APA (American Psychological Association) Style

Gupta, A., Singh, . S. K., Yadav, . J. S., Sharma, . H. B. & Chakravartty, . A. (2023) Comparison of brainstem auditory evoked potentials and event-related potential P300 parameter among different severity levels of depression: A study on adult patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1917-1922. doi:10.5455/njppp.2023.13.07334202304082023

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