A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease

Arun Kumar Singh; Lalit Prashant Meena; Arun Saravanan; Ravi Tandon

doi:10.5455/njppp.2015.5.230920141

2026, Vol: 16, Issue: 1

16 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 06 Apr 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(2): 105-107

doi: 10.5455/njppp.2015.5.230920141

A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease

Arun Kumar Singh, Lalit Prashant Meena, Arun Saravanan, Ravi Tandon.

Cited By:1

Abstract
Background: Nearly all smokers show some evidence of lung and systemic cellular and/or humoral inflammation, only a few will experience an amplified response and develop chronic obstructive pulmonary disease (COPD). Several studies have shown systemic inflammation in COPD patients with increased neutrophil, macrophage and T lymphocyte numbers, and high concentrations of inflammatory mediators in peripheral blood (C-reactive protein, interleukin (IL)-6, IL-8, and tumor necrosis factor-α (TNF-α)).

Aims and Objective: To study oxidative stress, antioxidant status, and TNF- levels in patients with COPD.

Materials and Methods: Forty-four COPD patients along with an equal number of age- and sex-matched controls were included in study. The levels of malondialdehyde (MDA; by thiobarbituric acid assay), assay of TNF-α (by TNF-α), and total antioxidant were measured.

Results: Malondialdehyde level was found to be significantly higher in all cases, and it was statistically significant in COPD patients with Global Initiative on Obstructive Lung Disease (GOLD) classification grades 2 and 3. Total antioxidant level was significantly lower in all the patients with COPD and was statistically significant in GOLD grades 2 and 3. Like MDA, TNF level was also significantly higher in all the cases with statistically significant increase in GOLD grades 2 and 3.

Conclusion: To better understand the role of these trace elements and oxidative stress in the pathogenesis and complications of COPD, it is recommended to carry out further clinical studies.

Key words: Chronic Obstructive Pulmonary, Disease (COPD); Oxidative Stress; Malondialdehyde (MDA); Tumor Necrosis Factor-α (TNF-α)

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Arun Kumar Singh Articles by Lalit Prashant Meena Articles by Arun Saravanan Articles by Ravi Tandon
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Singh AK, Meena LP, Saravanan A, Tandon R. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141

Web Style

Singh AK, Meena LP, Saravanan A, Tandon R. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. https://www.njppp.com/?mno=166942 [Access: November 04, 2025]. doi:10.5455/njppp.2015.5.230920141

AMA (American Medical Association) Style

Singh AK, Meena LP, Saravanan A, Tandon R. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141

Vancouver/ICMJE Style

Singh AK, Meena LP, Saravanan A, Tandon R. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol. (2015), [cited November 04, 2025]; 5(2): 105-107. doi:10.5455/njppp.2015.5.230920141

Harvard Style

Singh, A. K., Meena, . L. P., Saravanan, . A. & Tandon, . R. (2015) A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. Natl J Physiol Pharm Pharmacol, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141

Turabian Style

Singh, Arun Kumar, Lalit Prashant Meena, Arun Saravanan, and Ravi Tandon. 2015. A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141

Chicago Style

Singh, Arun Kumar, Lalit Prashant Meena, Arun Saravanan, and Ravi Tandon. "A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 105-107. doi:10.5455/njppp.2015.5.230920141

MLA (The Modern Language Association) Style

Singh, Arun Kumar, Lalit Prashant Meena, Arun Saravanan, and Ravi Tandon. "A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease." National Journal of Physiology, Pharmacy and Pharmacology 5.2 (2015), 105-107. Print. doi:10.5455/njppp.2015.5.230920141

APA (American Psychological Association) Style

Singh, A. K., Meena, . L. P., Saravanan, . A. & Tandon, . R. (2015) A study of oxidative stress, antioxidant status and TNF-α in chronic obstructive pulmonary disease. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 105-107. doi:10.5455/njppp.2015.5.230920141

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article