Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids

Rashmi Ramanathan; Manishankar Subramanian; Nagashree Ramasamy; Pushparaj Thangaraj; Jeyabanu Murugaiyan; Vinothkumar Selvaraj

doi:10.5455/njppp.2015.5.090920141

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Online Published: 06 Apr 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(2): 93-97

doi: 10.5455/njppp.2015.5.090920141

Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids

Rashmi Ramanathan, Manishankar Subramanian, Nagashree Ramasamy, Pushparaj Thangaraj, Jeyabanu Murugaiyan, Vinothkumar Selvaraj.

Cited By:3

Abstract
Background: Thyroid hormones exert effects on the heart and peripheral circulation. Heart rate variability (HRV) is a good
marker for identifying the cardiovascular risk in patients with hyperthyroidism.

Aims and Objective: To evaluate the impact of hyperthyroidism on autonomic tone and to compare the HRV parameters
in patients with hyperthyroidism and healthy volunteers.

Materials and Methods: This study was conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamil
Nadu, on 30 hyperthyroid patients (cases) with average age 39.23 ± 6.91 years and 30 healthy volunteers (controls) with
average age 42.13 ± 6.78 years. After obtaining the written consent from the subjects, ECG was recorded for 10 min in a
computerized physiograph in lead II.

Results: Statistical analysis carried out by independent Students t-test showed a significant difference (P < 0.001) in HRV
parameters of patients with hyperthyroid and healthy volunteers. Among the frequency domain measures, a decrease in
high frequency (HF) in normalized units and increase in low frequency (LF) in normalized units, and in the ratio of LF to HF
(LF/HF) in hyperthyroid patients was observed. Among the time domain measures, decrease in RR intervals, SDNN, RMSSD,
and NN50 was observed in patients with hyperthyroid compared to those with euthyroidism.

Conclusion: This study showed that individuals with hyperthyroidism had a higher sympathetic tone and a lower
parasympathetic tone as compared to those with euthyroidism. Using HRV analysis, we can identify patients who are at risk
for cardiac complications and early intervention can reduce mortality rates.

Key words: Heart Rate Variability (HRV); Hyperthyroidism; Euthyroidism; Autonomic Dysfunction

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Pubmed Style

Ramanathan R, Subramanian M, Ramasamy N, Thangaraj P, Murugaiyan J, Selvaraj V. Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 93-97. doi:10.5455/njppp.2015.5.090920141

Web Style

Ramanathan R, Subramanian M, Ramasamy N, Thangaraj P, Murugaiyan J, Selvaraj V. Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. https://www.njppp.com/?mno=167657 [Access: November 02, 2025]. doi:10.5455/njppp.2015.5.090920141

AMA (American Medical Association) Style

Ramanathan R, Subramanian M, Ramasamy N, Thangaraj P, Murugaiyan J, Selvaraj V. Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. Natl J Physiol Pharm Pharmacol. 2015; 5(2): 93-97. doi:10.5455/njppp.2015.5.090920141

Vancouver/ICMJE Style

Ramanathan R, Subramanian M, Ramasamy N, Thangaraj P, Murugaiyan J, Selvaraj V. Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. Natl J Physiol Pharm Pharmacol. (2015), [cited November 02, 2025]; 5(2): 93-97. doi:10.5455/njppp.2015.5.090920141

Harvard Style

Ramanathan, R., Subramanian, . M., Ramasamy, . N., Thangaraj, . P., Murugaiyan, . J. & Selvaraj, . V. (2015) Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. Natl J Physiol Pharm Pharmacol, 5 (2), 93-97. doi:10.5455/njppp.2015.5.090920141

Turabian Style

Ramanathan, Rashmi, Manishankar Subramanian, Nagashree Ramasamy, Pushparaj Thangaraj, Jeyabanu Murugaiyan, and Vinothkumar Selvaraj. 2015. Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 93-97. doi:10.5455/njppp.2015.5.090920141

Chicago Style

Ramanathan, Rashmi, Manishankar Subramanian, Nagashree Ramasamy, Pushparaj Thangaraj, Jeyabanu Murugaiyan, and Vinothkumar Selvaraj. "Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 93-97. doi:10.5455/njppp.2015.5.090920141

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ramanathan, R., Subramanian, . M., Ramasamy, . N., Thangaraj, . P., Murugaiyan, . J. & Selvaraj, . V. (2015) Comparative study on Spectral analysis of heart rate variability in hyperthyroid patients and euthyroids. National Journal of Physiology, Pharmacy and Pharmacology, 5 (2), 93-97. doi:10.5455/njppp.2015.5.090920141

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