E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective

Arijita Banerjee, Indu Khurana, Chand Singh Dhull.

Cited by (2)

Abstract
Background: Dissimilarities in the risk factors concerned with primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) suggest these two forms of glaucoma to be separate clinical entities, each having their own pathogenesis, yet the relationship between them is not clear convincing.

Aims and Objectives: The aim of the study was to compare the autonomic activity between healthy controls, POAG, and NTG patients by heart rate variability (HRV).

Materials and Methods: The study was conducted on 30 age- and sex-matched healthy controls (Group І), 30 patients with NTG (Group ІІ), and 30 patients with POAG (Group ІІІ) of age between 45 and 65 years. The basal HRV was analyzed at rest followed by stress tests, handgrip testing (HGT) and passive head-up tilt (HUT), and post recovery. Data obtained were statistically analyzed using SPSS 20.

Results: Significant raised values of low frequency variables (LF [nu] [58.94 ± 6.556] and [73.39 ± 4.04]) in Group ІІ and Group ІІІ, respectively, as compared to Group І (52.13 ± 2.97). LF/HF ratio was significantly rise in Groups ІІ and ІІІ with P < 0.000 during HGT. LF/HF ratio was significantly high (P < 0.006) and (P < 0.004) in Groups ІІ and ІІІ, respectively, as compared to Group І during HUT.

Conclusion: The above findings of HRV suggested greater withdrawal of vagal tone and persistently overdrive of sympathetic activity due to sympathovagal imbalance indicated ocular vascular alterations more in NTG than in POAG as compared to normal healthy subjects.

Key words: Autonomic Dysfunction; Heart Rate Variability; Vascular Dysregulation


 
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How to Cite this Article
Pubmed Style

Banerjee A, Khurana I, Dhull CS. Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 510-514. doi:10.5455/njppp.2019.9.0307323032019


Web Style

Banerjee A, Khurana I, Dhull CS. Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. https://www.njppp.com/?mno=35535 [Access: December 01, 2022]. doi:10.5455/njppp.2019.9.0307323032019


AMA (American Medical Association) Style

Banerjee A, Khurana I, Dhull CS. Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. Natl J Physiol Pharm Pharmacol. 2019; 9(6): 510-514. doi:10.5455/njppp.2019.9.0307323032019



Vancouver/ICMJE Style

Banerjee A, Khurana I, Dhull CS. Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. Natl J Physiol Pharm Pharmacol. (2019), [cited December 01, 2022]; 9(6): 510-514. doi:10.5455/njppp.2019.9.0307323032019



Harvard Style

Banerjee, A., Khurana, . I. & Dhull, . C. S. (2019) Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. Natl J Physiol Pharm Pharmacol, 9 (6), 510-514. doi:10.5455/njppp.2019.9.0307323032019



Turabian Style

Banerjee, Arijita, Indu Khurana, and Chand Singh Dhull. 2019. Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 510-514. doi:10.5455/njppp.2019.9.0307323032019



Chicago Style

Banerjee, Arijita, Indu Khurana, and Chand Singh Dhull. "Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 510-514. doi:10.5455/njppp.2019.9.0307323032019



MLA (The Modern Language Association) Style

Banerjee, Arijita, Indu Khurana, and Chand Singh Dhull. "Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective." National Journal of Physiology, Pharmacy and Pharmacology 9.6 (2019), 510-514. Print. doi:10.5455/njppp.2019.9.0307323032019



APA (American Psychological Association) Style

Banerjee, A., Khurana, . I. & Dhull, . C. S. (2019) Normal tension glaucoma versus primary open-angle glaucoma – The autonomic perspective. National Journal of Physiology, Pharmacy and Pharmacology, 9 (6), 510-514. doi:10.5455/njppp.2019.9.0307323032019