E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients

Rozy Paul, Ashok Kumar Kumawat.

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is the second most common cause of mortality in India. It is associated with cardiovascular dysautonomia. Heart rate (HR) variability is among the common non-invasive procedures to evaluate cardiac autonomic nervous activity.

Aims and Objectives: The aims of this study were to assess and compare HR variability in patients with COPD with healthy age- and sex-matched control subjects.

Materials and Methods: The cross-sectional study was performed in a tertiary care teaching institute (IEC No: 105/MC/EC/2020) from February 2021 to January 2022. A total of 60 individuals were studied with 30 COPD patients and 30 healthy age- and sex-matched persons as a control group. The unpaired student t-test was performed.

Results: The difference of mean height (cms, P ≤h0.09), mean age (P > 0.05), mean weight (P > 0.05), mean body mass index (P > 0.05), and mean HR (P > 0.05), between the two groups was non-significant. The mean (± SD) RR of cases and controls was 600 ± 312 and 756 ± 132, respectively. The difference among the two groups was statistically significant (P < 0.05). RMSSD and SDNN of both groups show an apparent decrease in the mean value of cases compared to healthy subjects (P = 0.02). The difference between pNN50 (P = 0.009) and NN50 (P = 0.02) among cases and controls was highly significant. The mean LF nu was higher (P = 0.002), mean HF nu was less (P = 0.001), and mean LF/HF was high (P = 0.03) among the cases than in the control group.

Conclusion: There is sympathetic hyperactivity and reduced parasympathetic activity in COPD patients as compared to healthy subjects, which is statistically significant. The study signifies the importance of non-invasive methods for screening autonomic function status in COPD patients.

Key words: Autonomic Functions; Cardiovascular; Chronic Obstructive Pulmonary Disease; Dysautonomia; Heart Rate Variability; Pulmonary


 
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Pubmed Style

Paul R, Kumawat AK. A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023


Web Style

Paul R, Kumawat AK. A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. https://www.njppp.com/?mno=116177 [Access: February 01, 2024]. doi:10.5455/njppp.2023.13.10480202213042023


AMA (American Medical Association) Style

Paul R, Kumawat AK. A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023



Vancouver/ICMJE Style

Paul R, Kumawat AK. A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol. (2023), [cited February 01, 2024]; 13(11): 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023



Harvard Style

Paul, R. & Kumawat, . A. K. (2023) A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. Natl J Physiol Pharm Pharmacol, 13 (11), 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023



Turabian Style

Paul, Rozy, and Ashok Kumar Kumawat. 2023. A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023



Chicago Style

Paul, Rozy, and Ashok Kumar Kumawat. "A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023



MLA (The Modern Language Association) Style

Paul, Rozy, and Ashok Kumar Kumawat. "A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients." National Journal of Physiology, Pharmacy and Pharmacology 13.11 (2023), 2224-2228. Print. doi:10.5455/njppp.2023.13.10480202213042023



APA (American Psychological Association) Style

Paul, R. & Kumawat, . A. K. (2023) A comparative study for assessment of heart rate variability in chronic obstructive pulmonary disease patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2224-2228. doi:10.5455/njppp.2023.13.10480202213042023