E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital

Kavitha V, Malathi K, Deepa S, Chenthamarai G.

Abstract
Background: Drug-drug interactions are quite prevalent, especially in the geriatric population with comorbidities. It affects the effectiveness, safety, and tolerability of the medications they use.

Aims and Objectives: This study aims to analyze and identify potential drug-drug interactions (pDDIs) in hypertensive patients using Medscape databases.

Materials and Methods: A prospective and observational study was conducted in the Hypertension clinic of KMC, Chennai, for 3 months during November 2019–January 2020. Hypertensive patients of both sexes attending hypertension clinics with an age of more than 18 years and taking more than two antihypertensive drugs were included in the study. The use of Medscape databases enabled the appropriate data to be gathered and evaluated for pDDIs.

Results: Three hundred patients in all were enrolled for the trial. One hundred and forty out of the 300 patients had pDDIs. Out of 140 patients, the majority (55%) were between the ages of 40 and 60. Males (56.4%) had a higher prevalence of pDDIs than females (43.6%). Atenolol, enalapril, and furosemide were the most frequently used medications in the present study that caused pDDIs, accounting for 29.8%, 19.5%, and 18.6%, respectively.

Conclusion: The prevalence of pDDIs was found to be 46.6% overall, and an increase in comorbidities and polypharmacy were revealed to be important risk factors for the emergence of several pDDIs. Most of the antihypertensives were shown to interact frequently with calcium carbonate.

Key words: Potential Drug-drug Interactions-pDDIs; Hypertension; Medscape Databases


 
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How to Cite this Article
Pubmed Style

V K, K M, S D, G C. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022


Web Style

V K, K M, S D, G C. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. https://www.njppp.com/?mno=126181 [Access: February 02, 2023]. doi:10.5455/njppp.2022.12.11511202207112022


AMA (American Medical Association) Style

V K, K M, S D, G C. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022



Vancouver/ICMJE Style

V K, K M, S D, G C. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2022), [cited February 02, 2023]; 12(12): 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022



Harvard Style

V, K., K, . M., S, . D. & G, . C. (2022) An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 12 (12), 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022



Turabian Style

V, Kavitha, Malathi K, Deepa S, and Chenthamarai G. 2022. An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022



Chicago Style

V, Kavitha, Malathi K, Deepa S, and Chenthamarai G. "An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022



MLA (The Modern Language Association) Style

V, Kavitha, Malathi K, Deepa S, and Chenthamarai G. "An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2184-2189. Print. doi:10.5455/njppp.2022.12.11511202207112022



APA (American Psychological Association) Style

V, K., K, . M., S, . D. & G, . C. (2022) An observational study on potential drug-drug interaction among hypertensive patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2184-2189. doi:10.5455/njppp.2022.12.11511202207112022