E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Oxidative stress in patients with diabetic nephropathy

Siby Jose, Razeena KC, Sanjeev Sankar Chandran.

Abstract
Background: Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. Oxidative stress which is classically defined as an event resulting from the magnitude of imbalance between oxidant and antioxidant substances, generated in a setting of oxidation-reduction reactions, and is hypothesized to play a role in the development of diabetic nephropathy.

Aim and Objectives: The aim of the study was to assess lipid peroxidation by estimating serum malondialdehyde (MDA) and antioxidant status by assaying paraoxonase-1 (PON-1) in diabetes patients with nephropathy and healthy controls. Furthermore, the study aimed the correlation between MDA and PON-1 levels in patients with diabetic nephropathy.

Materials and Methods: A cross-sectional comparative study was conducted in 152 participants, which were divided into two groups as control (n = 76) non-diabetic, healthy, age-, and sex-matched individuals and diabetic patients with nephropathy(n = 76). The study was conducted in Government Medical College, Kozhikode. All the subjects who satisfied the inclusion and exclusion criteria and who gave informed consent were included in a consecutive manner till sample size is achieved. Serum MDA and PON-1 were estimated using spectrophotometry. The data were analyzed using statistical package for the social sciences (SPSS) version 18.

Results: Oxidative stress was increased in diabetic nephropathy patients as evidenced by significantly elevated MDA and reduced PON-1 than the normal controls. There was a significant negative correlation of serum MDA with serum PON-1 in patients with diabetic nephropathy.

Conclusion: Oxidative stress is an important pathophysiological process for the development of diabetic nephropathy. This study reveals the importance of screening all diabetes patients for oxidative stress. Dietary management and antioxidant supplementation would help them to prevent development of diabetic nephropathy and related complications, which, in turn, improve their quality of life.

Key words: Oxidative Stress; Malondialdehyde; Paraoxonase 1; Diabetic Nephropathy


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Siby Jose
Articles by Razeena KC
Articles by Sanjeev Sankar Chandran
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Jose S, KC R, Chandran SS. Oxidative stress in patients with diabetic nephropathy. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022


Web Style

Jose S, KC R, Chandran SS. Oxidative stress in patients with diabetic nephropathy. https://www.njppp.com/?mno=13020 [Access: December 02, 2022]. doi:10.5455/njppp.2022.12.11326202119022022


AMA (American Medical Association) Style

Jose S, KC R, Chandran SS. Oxidative stress in patients with diabetic nephropathy. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022



Vancouver/ICMJE Style

Jose S, KC R, Chandran SS. Oxidative stress in patients with diabetic nephropathy. Natl J Physiol Pharm Pharmacol. (2022), [cited December 02, 2022]; 12(10): 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022



Harvard Style

Jose, S., KC, . R. & Chandran, . S. S. (2022) Oxidative stress in patients with diabetic nephropathy. Natl J Physiol Pharm Pharmacol, 12 (10), 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022



Turabian Style

Jose, Siby, Razeena KC, and Sanjeev Sankar Chandran. 2022. Oxidative stress in patients with diabetic nephropathy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022



Chicago Style

Jose, Siby, Razeena KC, and Sanjeev Sankar Chandran. "Oxidative stress in patients with diabetic nephropathy." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022



MLA (The Modern Language Association) Style

Jose, Siby, Razeena KC, and Sanjeev Sankar Chandran. "Oxidative stress in patients with diabetic nephropathy." National Journal of Physiology, Pharmacy and Pharmacology 12.10 (2022), 1709-1713. Print. doi:10.5455/njppp.2022.12.11326202119022022



APA (American Psychological Association) Style

Jose, S., KC, . R. & Chandran, . S. S. (2022) Oxidative stress in patients with diabetic nephropathy. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1709-1713. doi:10.5455/njppp.2022.12.11326202119022022