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Original Research

Online Publishing Date:
03 / 12 / 2020

 


Study of certain mechanisms of anti-edema action of dry extract of medicinal plants

Ziyovuddin Zaynutdinovich Khakimov, Alisher Khudayberdievich Rakhmanov, Shukhrat Ravshan O’g’li Mavlanov.


Abstract
Background: An actual problem of pharmacology is the search and development of new medications for treatment inflammatory diseases.

Aims and Objectives: The mechanism of the anti-edema action of dry extract of medicinal plants (DEMPs) was established in experiments using various phlogogens.

Materials and Methods: Experimental models of aseptic arthritis were reproduced by subplantar injection of dextran, histamine, and formalin in a volume of 0.1 ml into the hind paw of rats. The preventive effect of DEMP (50 mg/kg) was studied in comparison with diclofenac sodium (10 mg/ kg) and LIV-52 (100 mg/kg).

Results: It is believed that its mechanism is largely associated not only with the antioxidant property of the medication but also with the stimulation of the production of glucocorticoid hormones in the adrenal gland, as well as regulation of the level of pro- and anti-inflammatory interleukins, cortisol, and suppression of the formation of arachidonic acid.

Conclusions: The multicomponent mechanism of the anti-inflammatory action of DEMPs determines its high antiexudative, antiproliferative, and antialterative properties in inflammation with different etiologies.

Key words: Inflammation; Mechanism; Anti-Inflammatory Drugs; Hormones; Interleukins


 
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How to Cite this Article
Pubmed Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020

Web Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. https://www.njppp.com/?mno=132902 [Access: March 14, 2024]. doi:10.5455/njppp.2021.11.09240202021112020

AMA (American Medical Association) Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. 2021; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020


Vancouver/ICMJE Style

Khakimov ZZ, Rakhmanov AK, Mavlanov SRO. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol. (2021), [cited March 14, 2024]; 11(1): 89-95. doi:10.5455/njppp.2021.11.09240202021112020


Harvard Style

Khakimov, Z. Z., Rakhmanov, . A. K. & Mavlanov, . S. R. O. (2021) Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. Natl J Physiol Pharm Pharmacol, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020


Turabian Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O’g’li Mavlanov. 2021. Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020


Chicago Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O’g’li Mavlanov. "Study of certain mechanisms of anti-edema action of dry extract of medicinal plants." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 89-95. doi:10.5455/njppp.2021.11.09240202021112020


MLA (The Modern Language Association) Style

Khakimov, Ziyovuddin Zaynutdinovich, Alisher Khudayberdievich Rakhmanov, and Shukhrat Ravshan O’g’li Mavlanov. "Study of certain mechanisms of anti-edema action of dry extract of medicinal plants." National Journal of Physiology, Pharmacy and Pharmacology 11.1 (2021), 89-95. Print. doi:10.5455/njppp.2021.11.09240202021112020


APA (American Psychological Association) Style

Khakimov, Z. Z., Rakhmanov, . A. K. & Mavlanov, . S. R. O. (2021) Study of certain mechanisms of anti-edema action of dry extract of medicinal plants. National Journal of Physiology, Pharmacy and Pharmacology, 11 (1), 89-95. doi:10.5455/njppp.2021.11.09240202021112020


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