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Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema

Vinay Kumar Ksheerasagar, Venkatanarayana Narapogu, Princ Bgheal, Nagesh Chaganti.

Abstract
Background: Inflammation is described as a localized physical condition whereat part of the body becomes swollen, reddened, hot, and consistently painful, largely as a response to injury or infection.

Aim and Objectives: The current study is designed to study the Abutilon indicum for its anti-inflammatory activity in albino rats-induced paw edema by carrageenan.

Materials and Methods: Randomly 30 albino rats from both sexes were taken and divided into five groups, six in each. Normal saline 25 mL/kg (control), diclofenac 9 mg/kg (standard), and three different doses of plant extract (EEAI) such as 250, 500, and 1000 mg/kg (3 test groups) were given in respective groups, after 1-h injection of 0.1 mL of 0.2% carrageenan solution into the sub plantar region of the right hind paw. At 0 h, after 1, 2, and 3 h, paw edema volume was measured by mercury displacement method using plethysmograph. The percentage of edema inhibition was measured in all five groups.

Results: The percentage of edema inhibition for EEAI 500 mg/kg was 6.20%, 17.8%, and 26.72% after 1st, 2nd and 3rd h respectively and for EEAI 1000 mg/kg was 8.26%, 20.7%, 31.61% after 1st, 2nd, and 3rd h, respectively. Significant edema inhibition was observed after 2nd and 3rd h of drug administration (P < 0.05) in both groups treated with EEAI 500 and 1000 mg/kg.

Conclusion: Ethanolic extract of A. indicum had shown dose dependent anti-inflammatory activity.

Key words: Carrageenan; Diclofenac; Inflammation, Abutilon Indicum


 
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How to Cite this Article
Pubmed Style

Ksheerasagar VK, Narapogu V, Bgheal P, Chaganti N. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 607-610. doi:10.5455/njppp.2023.13.01003202323012023

Web Style

Ksheerasagar VK, Narapogu V, Bgheal P, Chaganti N. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. https://www.njppp.com/?mno=136179 [Access: September 04, 2023]. doi:10.5455/njppp.2023.13.01003202323012023

AMA (American Medical Association) Style

Ksheerasagar VK, Narapogu V, Bgheal P, Chaganti N. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 607-610. doi:10.5455/njppp.2023.13.01003202323012023


Vancouver/ICMJE Style

Ksheerasagar VK, Narapogu V, Bgheal P, Chaganti N. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. Natl J Physiol Pharm Pharmacol. (2023), [cited September 04, 2023]; 13(3): 607-610. doi:10.5455/njppp.2023.13.01003202323012023


Harvard Style

Ksheerasagar, V. K., Narapogu, . V., Bgheal, . P. & Chaganti, . N. (2023) Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. Natl J Physiol Pharm Pharmacol, 13 (3), 607-610. doi:10.5455/njppp.2023.13.01003202323012023


Turabian Style

Ksheerasagar, Vinay Kumar, Venkatanarayana Narapogu, Princ Bgheal, and Nagesh Chaganti. 2023. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 607-610. doi:10.5455/njppp.2023.13.01003202323012023


Chicago Style

Ksheerasagar, Vinay Kumar, Venkatanarayana Narapogu, Princ Bgheal, and Nagesh Chaganti. "Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 607-610. doi:10.5455/njppp.2023.13.01003202323012023


MLA (The Modern Language Association) Style

Ksheerasagar, Vinay Kumar, Venkatanarayana Narapogu, Princ Bgheal, and Nagesh Chaganti. "Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema." National Journal of Physiology, Pharmacy and Pharmacology 13.3 (2023), 607-610. Print. doi:10.5455/njppp.2023.13.01003202323012023


APA (American Psychological Association) Style

Ksheerasagar, V. K., Narapogu, . V., Bgheal, . P. & Chaganti, . N. (2023) Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 607-610. doi:10.5455/njppp.2023.13.01003202323012023


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