Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India

Shalabh Singla; Ranchit Narang; Vinay Shanker; Sharang Gupta; Neha Saraswat; Rajwinder Singh

doi:10.5455/njppp.2023.13.02072202313022023

2024, Vol: 14, Issue: 5

14 / 5Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Authorship Declaration

« Previous Article

Original Research

Online Publishing Date:
20 / 02 / 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1854-1857

doi: 10.5455/njppp.2023.13.02072202313022023

Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India

Shalabh Singla, Ranchit Narang, Vinay Shanker, Sharang Gupta, Neha Saraswat, Rajwinder Singh.

Abstract
Background: Alopecia areata is a disease, in which patients’ loss hairs as random patches due to autoimmune complications. Tofacitinib acts as an inhibiter in the Janus kinase signal transducer and activator of transcription pathway and is an effective drug approved for the of rheumatoid arthritis treatment. Limited evidence is available on the role of tofacitinib in treatment of alopecia areata.

Aim and Objective: The present study aims to evaluate the efficacy of tofacitinib in treatment of alopecia areata patients visiting the tertiary care center of North India.

Materials and Methods: Total 17 patients with alopecia areata were recruited in this study and prescribed with the tofacitinib 5 mg twice daily for 6 months. Severity of alopecia tool (SALT) was used to analyze the severity of hair loss. The SALT score measures the total percent of hair loss in all area of scalp. A higher SALT score indicates higher hair loss.

Results: The mean age of the patients was 27.88 ± 16.30 years with male-to-female sex ratio of 2.4:1. The mean duration of disease was 32.29 ± 22.14 months. There was a significant decrease in the SALT score (P = 0.0001) following the 6 months tofacitinib treatment.

Conclusion: Tofacitinib was found to be effective in the treatment of alopecia areata. Further multicentric studies with ample sample size are required to establish tofacitinib as a standard treatment for the alopecia areata.

Key words: Tofacitinib; Alopecia Areata; Scalp; Hair Loss; Severity of Alopecia Tool Score

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Shalabh Singla Articles by Ranchit Narang Articles by Vinay Shanker Articles by Sharang Gupta Articles by Neha Saraswat Articles by Rajwinder Singh
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Singla S, Narang R, Shanker V, Gupta S, Saraswat N, Singh R. Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Web Style

Singla S, Narang R, Shanker V, Gupta S, Saraswat N, Singh R. Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. https://www.njppp.com/?mno=143122 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.02072202313022023

AMA (American Medical Association) Style

Singla S, Narang R, Shanker V, Gupta S, Saraswat N, Singh R. Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. Natl J Physiol Pharm Pharmacol. 2023; 13(9): 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Vancouver/ICMJE Style

Singla S, Narang R, Shanker V, Gupta S, Saraswat N, Singh R. Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(9): 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Harvard Style

Singla, S., Narang, . R., Shanker, . V., Gupta, . S., Saraswat, . N. & Singh, . R. (2023) Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. Natl J Physiol Pharm Pharmacol, 13 (9), 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Turabian Style

Singla, Shalabh, Ranchit Narang, Vinay Shanker, Sharang Gupta, Neha Saraswat, and Rajwinder Singh. 2023. Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Chicago Style

Singla, Shalabh, Ranchit Narang, Vinay Shanker, Sharang Gupta, Neha Saraswat, and Rajwinder Singh. "Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

MLA (The Modern Language Association) Style

Singla, Shalabh, Ranchit Narang, Vinay Shanker, Sharang Gupta, Neha Saraswat, and Rajwinder Singh. "Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India." National Journal of Physiology, Pharmacy and Pharmacology 13.9 (2023), 1854-1857. Print. doi:10.5455/njppp.2023.13.02072202313022023

APA (American Psychological Association) Style

Singla, S., Narang, . R., Shanker, . V., Gupta, . S., Saraswat, . N. & Singh, . R. (2023) Analyzing the role of tofacitinib in treatment of alopecia areata: A retrospective analysis from a tertiary care center of North India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (9), 1854-1857. doi:10.5455/njppp.2023.13.02072202313022023

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article


About National Journal of Physiology, Pharmacy and Pharmacology National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal. The journal is having open access polic ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information Publisher publishernjppp@gmail.com Editorial query editornjppp1@gmail.com MOB - 8780040272