Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial

Dhruvika Chaudhry; Haramritpal Kaur; Mukesh Kumar; Amandeep Singh; Anmol Monga; Gurkirat Singh Bakshi

doi:10.5455/njppp.2023.13.02105202303032023

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Online Publishing Date:
13 / 03 / 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(10): 2029-2033

doi: 10.5455/njppp.2023.13.02105202303032023

Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial

Dhruvika Chaudhry, Haramritpal Kaur, Mukesh Kumar, Amandeep Singh, Anmol Monga, Gurkirat Singh Bakshi.

Abstract
Background: During general anesthesia (GA), muscle relaxants are routinely used drugs. Mostly they are administered as intermittent boluses; however, with the availability of novel molecules and meticulous monitoring, there is a shift of usage from intermitted to continuous infusion.

Aims and Objectives: The aim of the study was to compare intermitted and continuous infusion of administration of cisatracurium in regards to total dose consumption, mean infusion rate, duration of neuromuscular blockade, and recovery index.

Materials and Methods: The study was conducted on 60 adult patients undergoing GA with American Society of Anaesthesiologists Grade I and II. Patients were randomly distributed into two groups of 30 each. Group I received cisatracurium by continuous infusion while Group II received cisatracurium by intermittent bolus injection. The two groups were compared with regards to hemodynamic changes, total dose of cisatracurium consumption, mean infusion rate, neuromuscular blockade duration, recovery index, and any other adverse effect. Chi-square test, Student’s t-test, and paired sample t-test were used for statistical analysis.

Results: Intraoperative hemodynamics, neuromuscular blockade duration, and recovery index were comparable among the two groups (P > 0.05). The total dose of cisatracurium used in Group I was less being 7.3 ± 1.48 mg as compare to 8.27 ± 1.57 mg in Group II (P = 0.02). The mean infusion rate in Group I (0.96 ± 0.096 μg/kg/min) was significantly less as compared to Group II (1.11 ± 0.10 μg/kg/min) (P < 0.001).

Conclusions: Cisatracurium can be used effectively in both bolus as well as infusion form. However, continuous infusion gives the advantage of reduction of total dose of cisatracurium used and mean infusion rate.

Key words: Cisatracurium; Continuous Infusion; Intermittent Bolus; General Anesthesia

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How to Cite this Article

Pubmed Style

Chaudhry D, Kaur H, Kumar M, Singh A, Monga A, Bakshi GS. Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. Natl J Physiol Pharm Pharmacol. 2023; 13(10): 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

Web Style

Chaudhry D, Kaur H, Kumar M, Singh A, Monga A, Bakshi GS. Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. https://www.njppp.com/?mno=143942 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.02105202303032023

AMA (American Medical Association) Style

Chaudhry D, Kaur H, Kumar M, Singh A, Monga A, Bakshi GS. Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. Natl J Physiol Pharm Pharmacol. 2023; 13(10): 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

Vancouver/ICMJE Style

Chaudhry D, Kaur H, Kumar M, Singh A, Monga A, Bakshi GS. Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(10): 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

Harvard Style

Chaudhry, D., Kaur, . H., Kumar, . M., Singh, . A., Monga, . A. & Bakshi, . G. S. (2023) Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. Natl J Physiol Pharm Pharmacol, 13 (10), 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

Turabian Style

Chaudhry, Dhruvika, Haramritpal Kaur, Mukesh Kumar, Amandeep Singh, Anmol Monga, and Gurkirat Singh Bakshi. 2023. Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (10), 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

Chicago Style

Chaudhry, Dhruvika, Haramritpal Kaur, Mukesh Kumar, Amandeep Singh, Anmol Monga, and Gurkirat Singh Bakshi. "Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

MLA (The Modern Language Association) Style

Chaudhry, Dhruvika, Haramritpal Kaur, Mukesh Kumar, Amandeep Singh, Anmol Monga, and Gurkirat Singh Bakshi. "Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial." National Journal of Physiology, Pharmacy and Pharmacology 13.10 (2023), 2029-2033. Print. doi:10.5455/njppp.2023.13.02105202303032023

APA (American Psychological Association) Style

Chaudhry, D., Kaur, . H., Kumar, . M., Singh, . A., Monga, . A. & Bakshi, . G. S. (2023) Intermittent versus continuous infusion of cisatracurium in patients undergoing laparoscopic cholecystectomy: A prospective and randomized trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (10), 2029-2033. doi:10.5455/njppp.2023.13.02105202303032023

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