A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients

Apoorva B M; Kiran L J; Sushma H K; Nayana M R

doi:10.5455/njppp.2023.13.03122202317042023

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Online Publishing Date:
02 / 05 / 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2313-2318

doi: 10.5455/njppp.2023.13.03122202317042023

A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients

Apoorva B M, Kiran L J, Sushma H K, Nayana M R.

Abstract
Background: Topical corticosteroids are the effective anti-inflammatory agents prescribed following the cataract surgery. Their prolonged use can produce many side effects and one of them is steroid-induced glaucoma. Commonly used steroids in ocular therapy have tendency to cause rise in intraocular pressure (IOP). Elevated IOP if left untreated can ultimately progress to steroid-induced glaucoma. Any change in IOP should be monitored so that it can be detected and treated on time. Hence, the present study is planned.

Aims and Objectives: The aims and objectives of the study are to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on IOP in post-cataract surgery patients.

Materials and Methods: A total of 90 patients were randomly allocated into three groups of thirty each receiving prednisolone, dexamethasone, and difluprednate eye drops, respectively, for 6 weeks in a tapering dose. Pre-operative and post-operative IOP measurements were noted and the patients were followed up for 1½ months.

Results: Among 90 patients about 4.44% (n = 4) of them showed IOP elevation of ≥10 mmHg from baseline. About 14.44% (n = 13) patients showed moderate rise in IOP that is ≥5 mmHg. Clinically significant IOP elevation that is IOP increase of ≥10 mmHg and overall IOP of ≥21 mmHg was seen in 3.33% (n = 3) of the patients, and all of them belonged to difluprednate group. The mean post-operative IOP between the three treatment groups was not statistically significant.

Conclusion: Difluprednate is having a higher potential of causing early and significant rise in IOP and hence has to be used judiciously with constant monitoring.

Key words: Topical Corticosteroids; Steroid-Induced Glaucoma; Intraocular Pressure

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Pubmed Style

M AB, J KL, K SH, R NM. A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

Web Style

M AB, J KL, K SH, R NM. A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. https://www.njppp.com/?mno=145539 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.03122202317042023

AMA (American Medical Association) Style

M AB, J KL, K SH, R NM. A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

Vancouver/ICMJE Style

M AB, J KL, K SH, R NM. A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(11): 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

Harvard Style

M, A. B., J, . K. L., K, . S. H. & R, . N. M. (2023) A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. Natl J Physiol Pharm Pharmacol, 13 (11), 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

Turabian Style

M, Apoorva B, Kiran L J, Sushma H K, and Nayana M R. 2023. A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

Chicago Style

M, Apoorva B, Kiran L J, Sushma H K, and Nayana M R. "A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

MLA (The Modern Language Association) Style

M, Apoorva B, Kiran L J, Sushma H K, and Nayana M R. "A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients." National Journal of Physiology, Pharmacy and Pharmacology 13.11 (2023), 2313-2318. Print. doi:10.5455/njppp.2023.13.03122202317042023

APA (American Psychological Association) Style

M, A. B., J, . K. L., K, . S. H. & R, . N. M. (2023) A randomized controlled study to evaluate and compare the effect of prednisolone, dexamethasone, and difluprednate eye drops on intraocular pressure in post-cataract surgery patients. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2313-2318. doi:10.5455/njppp.2023.13.03122202317042023

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