E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of antinociceptive activity of minocycline in Swiss albino mice

Nithyapriya Manoharan, Madhan L, Sanu Sain, Malarvizhi R.

Abstract
Background: In an array of clinical diseases, pain management becomes increasingly complicated. The stimulation of glial cells and associations between neuroglial cells are emerging as being part of the primary mechanisms of pain. It has been observed that the tetracycline antibiotic minocycline inhibits microglial activation and thereby decreases nociception.

Aims and Objectives: The primary purpose of this study is to assess and compare the antinociceptive activity of minocycline with that of the conventional analgesic tramadol in Swiss albino mice.

Materials and Methods: Twenty-four Swiss albino mice in total were allocated into four groups, each including six mice. Using Eddy’s hot plate plus tail-flick procedure, the analgesic effects of tablet minocycline 5 mg/kg and tablet minocycline dose 10 mg/kg were assessed and compared to those of tramadol. Recordings of reaction time observations are made both before and after the administration of drugs. Results of a statistical analysis were obtained.

Results: Results of our study showed that in the tail-flick plus hot plate procedures, minocycline in doses of 5 mg/kg and 10 mg/kg had a significant (P < 0.05) antinociceptive effect in Swiss albino mice. However, the antinociceptive effect of minocycline is more when compared to distilled water, and is less when compared to standard analgesic tramadol.

Conclusion: Minocycline showed significant antinociceptive activity in both doses in Swiss albino mice.

Key words: Anti Nociception; Minocycline; Tramadol; Tail-Flick Method; Hot Plate Test


 
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How to Cite this Article
Pubmed Style

Manoharan N, L M, Sain S, R M. Evaluation of antinociceptive activity of minocycline in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023


Web Style

Manoharan N, L M, Sain S, R M. Evaluation of antinociceptive activity of minocycline in Swiss albino mice. https://www.njppp.com/?mno=147410 [Access: January 31, 2024]. doi:10.5455/njppp.2023.13.03155202318042023


AMA (American Medical Association) Style

Manoharan N, L M, Sain S, R M. Evaluation of antinociceptive activity of minocycline in Swiss albino mice. Natl J Physiol Pharm Pharmacol. 2023; 13(11): 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023



Vancouver/ICMJE Style

Manoharan N, L M, Sain S, R M. Evaluation of antinociceptive activity of minocycline in Swiss albino mice. Natl J Physiol Pharm Pharmacol. (2023), [cited January 31, 2024]; 13(11): 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023



Harvard Style

Manoharan, N., L, . M., Sain, . S. & R, . M. (2023) Evaluation of antinociceptive activity of minocycline in Swiss albino mice. Natl J Physiol Pharm Pharmacol, 13 (11), 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023



Turabian Style

Manoharan, Nithyapriya, Madhan L, Sanu Sain, and Malarvizhi R. 2023. Evaluation of antinociceptive activity of minocycline in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023



Chicago Style

Manoharan, Nithyapriya, Madhan L, Sanu Sain, and Malarvizhi R. "Evaluation of antinociceptive activity of minocycline in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023



MLA (The Modern Language Association) Style

Manoharan, Nithyapriya, Madhan L, Sanu Sain, and Malarvizhi R. "Evaluation of antinociceptive activity of minocycline in Swiss albino mice." National Journal of Physiology, Pharmacy and Pharmacology 13.11 (2023), 2323-2327. Print. doi:10.5455/njppp.2023.13.03155202318042023



APA (American Psychological Association) Style

Manoharan, N., L, . M., Sain, . S. & R, . M. (2023) Evaluation of antinociceptive activity of minocycline in Swiss albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 13 (11), 2323-2327. doi:10.5455/njppp.2023.13.03155202318042023