E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 5
14 / 5Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research

Online Publishing Date:
13 / 06 / 2023

 


Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial

Utsav Shinghal, Purshottam Kumar Kaundal, Shruti Sharma.


Abstract
Background: Functional constipation (FC) is a common childhood problem worldwide. At present, polyethylene glycol (PEG) is considered as standard therapy in pediatric FC patients.

Aims and Objectives: The aim of the study was to compare the efficacy of PEG 3350 versus psyllium in treatment of pediatric FC.

Materials and Methods: All children (aged >1 year) diagnosed with FC according to Rome IV criteria and presenting to the outpatient department of Pediatric Gastroenterology, Hepatology, and Nutrition Unit of a tertiary health center in North Indian Himalayan state were randomized into two open label, prospective, parallel groups, namely, Group A (receiving PEG 3350) and Group B (receiving psyllium), over a period of 16 months. The comparative efficacy was evaluated by comparing the percent of patients with successful outcomes in two groups at 4, 8, and 12 weeks of therapy and the rate of recurrence of impaction in two groups was also assessed and compared over same period.

Results: Eighty-one patients were randomized into two groups. A significantly higher number of patients in Group A was successfully treated after 4 weeks (Group A 68.3% vs. Group B 42.5%; P = 0.026), 8 weeks (Group A 80.0% vs. Group B 57.9%; P = 0.049), and 12 weeks (Group A 92.3% vs. Group B 67.6%; P = 0.009) of treatment compared with Group B. Impaction recurred in two patients in Group B while no recurrence was observed in any of the Group A patients but the difference observed was not statistically significant (P = 0.494). No significant adverse events were reported in either groups.

Conclusion: PEG 3350 was found to be significantly more effective than psyllium in improving the symptoms of constipation in pediatric patients.

Key words: Functional Constipation; Polyethylene Glycol; Psyllium; Rome IV Criteria


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Utsav Shinghal
Articles by Purshottam Kumar Kaundal
Articles by Shruti Sharma
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023

Web Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. https://www.njppp.com/?mno=155182 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.05290202305062023

AMA (American Medical Association) Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


Vancouver/ICMJE Style

Shinghal U, Kaundal PK, Sharma S. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(7): 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


Harvard Style

Shinghal, U., Kaundal, . P. K. & Sharma, . S. (2023) Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. Natl J Physiol Pharm Pharmacol, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


Turabian Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. 2023. Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


Chicago Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. "Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


MLA (The Modern Language Association) Style

Shinghal, Utsav, Purshottam Kumar Kaundal, and Shruti Sharma. "Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial." National Journal of Physiology, Pharmacy and Pharmacology 13.7 (2023), 1520-1525. Print. doi:10.5455/njppp.2023.13.05290202305062023


APA (American Psychological Association) Style

Shinghal, U., Kaundal, . P. K. & Sharma, . S. (2023) Comparative efficacy of polyethylene glycol 3350 and psyllium in treatment of pediatric functional constipation: A randomized and controlled trial. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1520-1525. doi:10.5455/njppp.2023.13.05290202305062023


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

  National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Publisher

publishernjppp@gmail.com

 

Editorial query

editornjppp1@gmail.com

MOB - 8780040272