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Original Research

Online Publishing Date:
20 / 11 / 2023

 


Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes

Avinash P Kulkarni, Manila Jain, Sanjay Dattatraya Bhalerao.


Abstract
Background: Pre-diabetes is a critical stage with a risk of developing Type 2 diabetes mellitus and it is there is solid evidence of impaired glucose metabolism among the patients. Insulin resistance is the frequent finding and is a key factor in pre-diabetes but its specific relationship with fasting glucose and fasting insulin levels requires further exploration.

Aims and Objectives: This study aimed to investigate the correlation of fasting glucose and fasting insulin levels in subjects with pre-diabetes.

Materials and Methods: A total of 86 individuals with pre-diabetes (subjects having a level of fasting blood sugar of 100–125 mg/dL) were recruited for this cross-sectional study. Fasting glucose and fasting insulin levels were measured with an 8-h fasting for all the participants of the study who had been diagnosed as pre-diabetes. The Pearson correlation was carried out to evaluate the relationships between fasting glucose and fasting insulin levels.

Results: This study included 86 people (56 male and 30 female) with an average age of 42.57 ± 7.58 years. Males had a greater age, height, weight, and BMI. Similarly, no gender differences in blood sugar or insulin levels were seen. FBS and serum insulin levels had a positive connection (r = 0.19, P = 0.038).

Conclusion: Our study revealed a robust positive correlation between fasting blood sugar and fasting insulin levels in individuals with pre-diabetes. These findings emphasize the need for early intervention and tailored strategies to address insulin resistance in pre-diabetic individuals to mitigate the risk of progressing to Type 2 diabetes.

Key words: Insulin; Fasting Glucose; Fasting Sugar; Diabetes; Obesity


 
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How to Cite this Article
Pubmed Style

Kulkarni AP, Jain M, Bhalerao SD. Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. Natl J Physiol Pharm Pharmacol. 2023; 13(12): 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023

Web Style

Kulkarni AP, Jain M, Bhalerao SD. Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. https://www.njppp.com/?mno=175135 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.10513202314112023

AMA (American Medical Association) Style

Kulkarni AP, Jain M, Bhalerao SD. Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. Natl J Physiol Pharm Pharmacol. 2023; 13(12): 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


Vancouver/ICMJE Style

Kulkarni AP, Jain M, Bhalerao SD. Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(12): 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


Harvard Style

Kulkarni, A. P., Jain, . M. & Bhalerao, . S. D. (2023) Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. Natl J Physiol Pharm Pharmacol, 13 (12), 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


Turabian Style

Kulkarni, Avinash P, Manila Jain, and Sanjay Dattatraya Bhalerao. 2023. Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. National Journal of Physiology, Pharmacy and Pharmacology, 13 (12), 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


Chicago Style

Kulkarni, Avinash P, Manila Jain, and Sanjay Dattatraya Bhalerao. "Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


MLA (The Modern Language Association) Style

Kulkarni, Avinash P, Manila Jain, and Sanjay Dattatraya Bhalerao. "Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes." National Journal of Physiology, Pharmacy and Pharmacology 13.12 (2023), 2516-2519. Print. doi:10.5455/njppp.2023.13.10513202314112023


APA (American Psychological Association) Style

Kulkarni, A. P., Jain, . M. & Bhalerao, . S. D. (2023) Association of fasting glucose and fasting insulin levels: Insights into the mechanisms of pre-diabetes. National Journal of Physiology, Pharmacy and Pharmacology, 13 (12), 2516-2519. doi:10.5455/njppp.2023.13.10513202314112023


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