E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 5
14 / 5Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research

Online Publishing Date:
29 / 12 / 2023

 


Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion

Sumalatha V, Maruthi Prasad, Basavaraju TJ.


Abstract
Background: Tuberculous pleural effusion (TPE) is a prominent clinical manifestation of extrapulmonary tuberculosis (TB). Traditional diagnostic markers often face challenges in sensitivity or specificity, necessitating the exploration of newer, more effective biomarkers.

Aims and Objectives: This study aimed to evaluate the diagnostic potential of adenosine deaminase (ADA) in pleural fluid as an early indicator for TPE and to analyze its correlation with interferongamma (IFNγ) levels.

Materials and Methods: We conducted a case–control study involving 100 patients: 50 diagnosed with TPE (cases) and 50 with non-TPE (controls). Pleural fluid samples from these patients were subjected to ADA and IFNγ level assessments using standardized protocols. Routine TB markers were concurrently examined.

Results: The findings indicated significantly heightened ADA levels compared to controls in cases. IFNγ levels were similarly elevated in patients versus controls. A weak positive correlation was established between ADA and IFNγ in cases with an R-value of 0.1016.

Conclusion: Our study underscores the potential of ADA in pleural fluid as a promising early diagnostic marker for TPE. Although the correlation with IFNγ is weak, it reinforces the proposition of combining multiple biomarkers to enhance diagnostic precision.

Key words: Adenosine Deaminase; Pleural Fluid; Tuberculous Pleural Effusion; Interferon-Gamma; Extrapulmonary Tuberculosis; Pleural Effusion Diagnosis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sumalatha V
Articles by Maruthi Prasad
Articles by Basavaraju TJ
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

V S, Prasad M, TJ B. Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 118-122. doi:10.5455/njppp.2023.13.11538202321122023

Web Style

V S, Prasad M, TJ B. Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. https://www.njppp.com/?mno=175386 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.11538202321122023

AMA (American Medical Association) Style

V S, Prasad M, TJ B. Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. Natl J Physiol Pharm Pharmacol. 2024; 14(1): 118-122. doi:10.5455/njppp.2023.13.11538202321122023


Vancouver/ICMJE Style

V S, Prasad M, TJ B. Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. Natl J Physiol Pharm Pharmacol. (2024), [cited March 14, 2024]; 14(1): 118-122. doi:10.5455/njppp.2023.13.11538202321122023


Harvard Style

V, S., Prasad, . M. & TJ, . B. (2024) Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. Natl J Physiol Pharm Pharmacol, 14 (1), 118-122. doi:10.5455/njppp.2023.13.11538202321122023


Turabian Style

V, Sumalatha, Maruthi Prasad, and Basavaraju TJ. 2024. Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 118-122. doi:10.5455/njppp.2023.13.11538202321122023


Chicago Style

V, Sumalatha, Maruthi Prasad, and Basavaraju TJ. "Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 118-122. doi:10.5455/njppp.2023.13.11538202321122023


MLA (The Modern Language Association) Style

V, Sumalatha, Maruthi Prasad, and Basavaraju TJ. "Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion." National Journal of Physiology, Pharmacy and Pharmacology 14.1 (2024), 118-122. Print. doi:10.5455/njppp.2023.13.11538202321122023


APA (American Psychological Association) Style

V, S., Prasad, . M. & TJ, . B. (2024) Evaluating the efficacy of adenosine deaminase in pleural fluid as an early indicator for tuberculous pleural effusion. National Journal of Physiology, Pharmacy and Pharmacology, 14 (1), 118-122. doi:10.5455/njppp.2023.13.11538202321122023


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

  National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Publisher

publishernjppp@gmail.com

 

Editorial query

editornjppp1@gmail.com

MOB - 8780040272