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Original Research 


Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle

Yogita D Sulaxane, Sharad G Patel.

Cited by (1)

Abstract
Background: The physiologic mechanisms whereby the human endometrium maintains hemostasis during endovascular trophoblast invasion, yet permits menstrual hemorrhage, are unknown.

Aims and Objective: To find out whether hemostatic responses alter during various phases of normal menstruation.

Materials and Methods: In this study height, weight, body mass index, pulse, and blood pressure were measured in 60 female volunteers having normal, regular menstrual cycle. Bleeding and clotting time were measured during three phases of single menstrual cycle: menstrual, follicular, and luteal. One-way analysis of variance test with Bonferroni correction was used to find out statistical significance.

Results: This study shows mean bleeding time at follicular phase was significantly (P < 0.05) less as compared to that at menstrual and luteal phases. Mean clotting time at follicular phase was comparatively less than that at menstrual and luteal phases, but the difference was not significant (P > 0.05).

Conclusion: Our observations indicate that primary and secondary hemostatic mechanism activities are at their high in the follicular phase than in the luteal and menstrual phases.

Key words: Menstrual Cycle; Bleeding Time; Clotting Time; Hemostasis


 
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REFERENCES
1. Philipp CS, Faiz A, Dowling N, Dilley A, Michaels LA, Ayers C, et al. Age and the prevalence of bleeding disorders in women with menorrhagia. Obstet Gynecol. 2005;105:61-6. [DOI via Crossref]    [Pubmed]   
2. Lockwood CJ, Krikun G, Papp C, Zhou X, Hausknecht V, Papp Z, et al. The role of progestationally regulated stromal cell tissue factor and type-1 plasminogen activator inhibitor (PAI-1) in endometrial hemostasis and menstruation. Ann N Y Acad Sci. 1994;734: 57-79. [DOI via Crossref]    [Pubmed]   
3. Datta DC. Textbook of Gynaecology including Contraception, 4th edn. Calcutta: New Central Book Agency, 2005.
4. Hall JE. Guyton and Hall Textbook of Medical Physiology, 12th edn. New Delhi: Elsevier, 2011.
5. Hahn L, Rybo G. Fibrinogen-fibrin degradation products in menstrual blood from women with normal and excessive menstrual losses. Acta Obstet Gynecol Scand. 1975;54(2): 119-27. [DOI via Crossref]    [Pubmed]   
6. Feuring M, Christ M, Roell A, Schueller P, Losel R, Dempfle CE, et al. Alterations in platelet function during the ovarian cycle. Blood Coagul Fibrinolysis. 2002;13(5):443-7. [DOI via Crossref]    [Pubmed]   
7. Farsetti A, Misiti S, Citarella F, Felici A, Andreoli M, Fantoni A, et al. Molecular basis of estrogen regulation of Hageman factor XII gene expression. Endocrinology. 1995;136(11):5076-83. [Pubmed]   
8. Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, et al. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Blood. 2000;95(7):2289-96. [Pubmed]   
9. Nagata Y, Yoshikawa J, Hashimoto A, Yamamoto M, Payne AH, Todokoro K. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev. 2003;17:2864-9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Jayachandran M, Karnicki K, Miller RS, Owen WG, Korach KS, Miller VM. Platelet characteristics change with aging: role of estrogen receptor beta. J Gerontol A Biol Sci Med Sci. 2005;60(7):815-9. [DOI via Crossref]    [Pubmed]   
11. van Eijkeren MA, Christiaens GC, Geuze HJ, Haspels AA, Sixma JJ. Effects of mefenamic acid on menstrual hemostasis in essential menorrhagia. Am J Obstet Gynecol. 1992;166(5):1419-28. [DOI via Crossref]   
12. Marieke H, Dick H, Hanneke C, Ate GJ, Jan VDM, Karina M. Routine evaluation and treatment of unexplained menorrhagia: do we consider hemostatic disorders? Eur J Obstet Gynecol Reprod Biol. 2010;152(2):191-4. [DOI via Crossref]    [Pubmed]   
13. Mehran K, Abdolreza A, Sedighe A, Jale Z, Shiva N, Mohainmadreza B, et al. Coagulation disorders in women with idiopathic menorrhagia. Asia-Pacific J Oncol Hematol. 2010;2(1):19.
14. Ghosh K, Trasi S, Nair S, Shetty S, Mohanty D. Prevalence of inherited bleeding disorders in cases of idiopathic menorrhagia: a case of five blind men describing an elephant. J Thromb Hemost. 2003;1(10):2242-3. [DOI via Crossref]   
15. Saxena R, Gupta M, Gupta PK, Kashyap R, Choudhary VP, Bhargava M. Inherited bleeding disorders in Indian women with menorrhagia. Hemophilia. 2003;9:193-6. [DOI via Crossref]   
16. Greer JP, Foerster J, Lukens JN (Eds.). Wintrobe’s Clinical Hematology, 11th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2003.
17. Roell A, Schueller P, Schultz A, Losel R, Wehling M, Christ M, et al. Effect of oral contraceptives and ovarian cycle on platelet function. Platelets. 2007;18:165-70. [DOI via Crossref]    [Pubmed]   
18. Kadir RA, Economides DL, Sabin CA, Owens D, Lee CA. Variations in coagulation factors in women: effects of age, ethnicity, menstrual cycle and combined oral contraceptive. Thromb Haemost. 1999;82:1456-61. [Pubmed]   
19. Miller CH, Dilley AB, Drews C, Richardson L, Evatt B. Changes in von Willebrand factor and factor VIII levels during the menstrual cycle. Thromb Haemost. 2002;87:1082-3. [Pubmed]   
20. Koh SC, Prasad RN, Fong YF. Hemostatic status and fibrinolytic response potential at different phases of the menstrual cycle. Clin Appl Thromb Hemost. 2005;11:295-301. [DOI via Crossref]    [Pubmed]   
21. Knol H, Kemperman RF, Kluin-Nelemans HC, Mulder AB, Meijer K. Hemostatic variables during normal menstrual cycle. Thromb Haemost. 2012;107:22-9. [DOI via Crossref]    [Pubmed]   

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1
 
How to Cite this Article
Pubmed Style

Yogita D Sulaxane, Sharad G Patel. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536

Web Style

Yogita D Sulaxane, Sharad G Patel. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. https://www.njppp.com/?mno=175878 [Access: December 01, 2022]. doi:10.5455/njppp.2015.5.3001201536

AMA (American Medical Association) Style

Yogita D Sulaxane, Sharad G Patel. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536


Vancouver/ICMJE Style

Yogita D Sulaxane, Sharad G Patel. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol. (2015), [cited December 01, 2022]; 5(4): 328-332. doi:10.5455/njppp.2015.5.3001201536


Harvard Style

Yogita D Sulaxane, Sharad G Patel (2015) Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. Natl J Physiol Pharm Pharmacol, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536


Turabian Style

Yogita D Sulaxane, Sharad G Patel. 2015. Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536


Chicago Style

Yogita D Sulaxane, Sharad G Patel. "Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 328-332. doi:10.5455/njppp.2015.5.3001201536


MLA (The Modern Language Association) Style

Yogita D Sulaxane, Sharad G Patel. "Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 328-332. Print. doi:10.5455/njppp.2015.5.3001201536


APA (American Psychological Association) Style

Yogita D Sulaxane, Sharad G Patel (2015) Cyclic fluctuation of bleeding time and clotting time in various phases of menstrual cycle. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 328-332. doi:10.5455/njppp.2015.5.3001201536


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