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Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi.

Cited by (1)

Abstract
Background: Tamarindus indica L is widely used as a traditional medicine. In Indonesia T. indica L is commonly used to treat gastritis, rheumatism, constipation, and fever.

Aims and Objective: The purpose of this study was to examine the hypolipidemic effect of 70% ethanolic extract of T. indica L fruit flesh and rind and their chemical compounds.

Materials and Methods: A total of 40 Wistar male rats were divided into 8 groups. group I was negative control (aquabidest); group II was positive control (Simvastatin 0.72 mg/gbw); groups III, IV, and V were treated by 70% ethanolic extract of the flesh fruit with doses of 200, 100, and 50 mg/kgbw, respectively; groups VI, VII, and VIII were treated by 70% ethanolic extract of the rind fruit with doses of 200, 100, and 50 mg/kgbw, respectively. The extract was given for 7 days after the third day. Measurement of plasma total cholesterol and triglyceride were carried out on days 0, 3, and 10.

Result: The results show that the 70% ethanolic extract of T. indica L fruit rind and flesh with doses of 200, 100, and 50 mg/kgbw can reduce plasma total cholesterol and triglyceride significantly (P < 0.01). Chemical content of 70% ethanolic extract of T. indica L fruit rind and flesh by thin-layer chromatography examination are alkaloids, flavonoids, terpenoids, and phenolic.

Conclusion: The 70% ethanolic extract of T. indica L fruit flesh and rind exert effect for lowering total cholesterol and triglyceride on hyperlipidemia induced by Triton X-100 in Wistar rats.

Key words: Tamarindus indica L, total cholesterol, triglycerides, Triton X-100


 
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1
 
How to Cite this Article
Pubmed Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537

Web Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. https://www.njppp.com/?mno=181925 [Access: December 01, 2022]. doi:10.5455/njppp.2015.5.0903201537

AMA (American Medical Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537


Vancouver/ICMJE Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. (2015), [cited December 01, 2022]; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537


Harvard Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi (2015) Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537


Turabian Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. 2015. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537


Chicago Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. "Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 285-290. doi:10.5455/njppp.2015.5.0903201537


MLA (The Modern Language Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. "Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 285-290. Print. doi:10.5455/njppp.2015.5.0903201537


APA (American Psychological Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi (2015) Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537


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