E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi.

Cited by (1)

Abstract
Background: Tamarindus indica L is widely used as a traditional medicine. In Indonesia T. indica L is commonly used to treat gastritis, rheumatism, constipation, and fever.

Aims and Objective: The purpose of this study was to examine the hypolipidemic effect of 70% ethanolic extract of T. indica L fruit flesh and rind and their chemical compounds.

Materials and Methods: A total of 40 Wistar male rats were divided into 8 groups. group I was negative control (aquabidest); group II was positive control (Simvastatin 0.72 mg/gbw); groups III, IV, and V were treated by 70% ethanolic extract of the flesh fruit with doses of 200, 100, and 50 mg/kgbw, respectively; groups VI, VII, and VIII were treated by 70% ethanolic extract of the rind fruit with doses of 200, 100, and 50 mg/kgbw, respectively. The extract was given for 7 days after the third day. Measurement of plasma total cholesterol and triglyceride were carried out on days 0, 3, and 10.

Result: The results show that the 70% ethanolic extract of T. indica L fruit rind and flesh with doses of 200, 100, and 50 mg/kgbw can reduce plasma total cholesterol and triglyceride significantly (P < 0.01). Chemical content of 70% ethanolic extract of T. indica L fruit rind and flesh by thin-layer chromatography examination are alkaloids, flavonoids, terpenoids, and phenolic.

Conclusion: The 70% ethanolic extract of T. indica L fruit flesh and rind exert effect for lowering total cholesterol and triglyceride on hyperlipidemia induced by Triton X-100 in Wistar rats.

Key words: Tamarindus indica L, total cholesterol, triglycerides, Triton X-100


 
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REFERENCES
1. Grundy SM. Cholesterol and coronary heart disease: a new era. J Am Med Assoc. 1986;256:2849-58. [DOI via Crossref]   
2. World Health Organisation. 2013. Cardiovascular Disease. Available at: http://www.who.int/mediacentre/factsheets/fs317/en/index.html (accessed June19, 2013).
3. Sastroamijoyo S. Obat asli Indonesia. Jakarta: Dian Rakyat, 2001. pp. 9-13.
4. Handayani T, Hartini S. Kajian Terhadap Kegunaan dan Upaya Pelestarian Asam Jawa. LIPI. Bogor. 2001. pp. 12-18.
5. Ismail Manal F, El-Maraghy Shohda A, Sadik Nermin AH. Sudy of the immunomodulatory and anti-inflammatory effects of evening primrose oil in adjuvant arthritis. Africa J Bioch Res. 2008;2(3):74-80.
6. Wan Chong UR, Abdul-Rahman PS, Abdul-Aziz A, Hashim OH, Junit SM. Tamarindus indica extract alters release of alpha enolase, apolipoprotein A-I, transthyretin and Rab GDP dissociation inhibitor beta from HepG2 cells. PLoS One. 2012;7(6):e39476. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
7. Sudjaroen Y, Haubner R, Wurtele G, Hull WE, Erben G, Spiegelhalder B. Isolation and structure elucidation of phenolic antioxidants from tamarind (Tamarindus indica L.) seeds and pericarp. Food Chem Toxicol. 2005;43:1673-82. [DOI via Crossref]    [Pubmed]   
8. Ferrara L. Antioxidant activity of Tamarindus indica L. Ingredienti Aliment. 2005;4(6):13-15.
9. Martinello F, Soares SM, Franco JJ, Santos AC, Sugohara A, Garcia SB. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters., Food Chem Toxicol. 2006;44(6):810-18. [DOI via Crossref]    [Pubmed]   
10. Pousset JL. Plantes médicinales africaine, Utilisations Pratiques. Ellipses. (ed) Paris, 1989. p. 95.
11. Doughari JH. Antimicrobial activity of Tamarindus indica Linn, Trop J Pharm. Res. 2006;5(2):597-603.
12. Maiti R, Jana D, Das UK, Ghosh D. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2004;92(1):85-91. [DOI via Crossref]    [Pubmed]   
13. Nahar L, Nasrin F, Zahan R, Haque A, Haque E, Mosaddik A. Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity. Pharmacognisy Res. 2014;6(2):180-7. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
14. Manoharan S, Chellammal A, Linsamary A, Vasudevan K, Balakrishnan S, Ranezab Anishkumar P. Antidiabetic efficacy of tamarindus indica seeds in alloxan induced diabetic rats. Electron J Pharmacol Ther. 2009;2:13-8.
15. Roy MG, Rahman S, Rehana F, Munmun M, Sharmin N, Hasan Z, et al. Evaluation of anti-hyperglycemic potential of methanolic extract of Tamarindus indica L. (Fabaceae) fruits and seeds in glucose-induced hyperglycemic mice. Adv Nat Appl Sci. 2010;4:159-62.
16. Ramachander T, Rajkumar D, Sravanprasad M, Goli V, Dhanalakshmi CH, Arjun. Antidiabetic activity of aqueous methanolic extracts of leaf of Tamarindus indica. Int J Pharmacogn Phytochem Res. 2012;4:5-7.
17. Hamidreza H, Heidari Z, Shahraki M, Moudi B. A stereological study of effects of aqueous extract of Tamarindus indica seeds on pancreatic islets in streptozotocin-induced diabetic rats. Pak J Pharm Sci. 2010;23(4):427-34. [Pubmed]   
18. Kobayashi A, Adenan ML, Kajiyama SI, Kanzaki H, Kawazu K. A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues. J Bio Sci. 1996;51:233-42.
19. Rimbau V, Cerdan C, Vila C, Iglesias J. Anti-inflammatory activity of some extract from plants used in the traditional medicines of North-African countries (II). Phytother Res. 1999;13(2):128-32. [DOI via Crossref]   
20. Iftekhar AS, Rayhan I, Quadir MA, Akhteruzzaman SA, Hasant A. Effect of Tamarindus indica fruits on blood pressure and lipidprofile in human model: An in vivo approach. Pak J Pharm Sci. 2006;19:125-8. [Pubmed]   
21. Ali N, Shah SWA. Spasmolytic activity of fruits of Tamarindus indica L. J Young Pharm.2010;2(3):261-4. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
22. Pimple BP, Kadam PV, Badgujar NS, Bafna AR, Patil MJ. Protective effect of Tamarandus indica Linn against paracetamol induced hepatotoxicity in rats. Indian J Pharm Sci. 2007;69:827-31. [DOI via Crossref]   
23. Babaria P. Mute M, Awari D, Ghodasara J. In vivo evaluation of antiarthritic activity of seed coat of Tamarindus indica Linn. Int J Pharm Pharmaceut Sci. 2011;3(4):204-7.
24. Kalra P, Sharma S, Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. J Pharm Bioallied Sci. 2011;3(2):236-41. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
25. Tayade PM, Ghaisas MM, Jagtap SA, Dongre SH. Anti-asthmatic activity of methanolic extract of leaves of Tamarindus indica Linn. J Pharm Res. 2009;2:944-7.
26. Bhat RB, Eterjere EO, Oladipo VT. Ethnobotanical studies from Central Nigeria. Econ Bot. 1990;44:382-90. [DOI via Crossref]   
27. Sundari D, Winarno MW. Efek laksatif jus daun asam jawa (Tamarindus indica Linn.) pada tikus putih yang diinduksi dengan gambir. Media Penelitian dan Pengembangan. Kesehatan. 2010;20(3):100-3.
28. Khan RA, Siddiqui SA, Azhar I, Ahmed SP. Preliminary screening of methanol and butanol extract of Tamarindus indica for antiemetic activity. J Basic Sci. 2005;1:51-4.
29. Sampat VM, Mute VM, Patel KA. Anthelmintic effect of Tamarind indica Linn leaves juice extract on pheretima posthuma. Int J Res Dev. 2009;1:1-6.
30. Gosain S, Ircchiaya R, Sharma CP, Tharejad S, Kalra A, Deep A, et al. Hypolipidemic effect of ethanolic extract from the leaves of hibiscus sabdariffa L in hyperlipidemic rats. Acta Pol Pharm Drug Res. 2010;67(2):179-84.
31. Kellner A, Correll JW, Ladd AT. Sustained hyperlipidemia induced in rabbits by means of intravenously injected surface-active agents. J Exp Med. 1951;93:373-84. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
32. Jindal V, Dhingra D, Sharma S, Parle M, Harna RK. Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats. J Pharmacol Pharmacother. 2011;2(2):80-4. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
33. Azman KF, Amom Z, Azlan A, Esa NM, Ali RM, Shah ZM, Kadir KK. Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats. J Nat Med. 2012;66(2):333-42. [DOI via Crossref]    [Pubmed]   
34. Koyagura N, Kumar VH, Jamadar MG, Huilgol SV, Nayak N, Yendigeri SM, Shamsuddin M. Antidiabetic and hepatoprotective activities of Tamarindus indica fruit pulp in alloxan induced diabetic rats. Int J Pharmacol Clin Sci. 2013;2(2):33-40.
35. Iftekhar ASMM, Rayhan I, Quadir MA, Akhteruzzaman S, Hasnat A. Effect of Tamarindus indica fruits on blood pressure and lipid-profile in human model: an in vivo approach. Pak J Pharm Sci. 2006;19(2): 125-9. [Pubmed]   
36. Yerima M, Anuka JA, Salawu OA, Abdu-Aguye I. Effect of stem-bark extract of Tamarindus indica L. on serum lipid profile, liver enzymes and blood glucose level of experimentally induced hyperglycaemic Wistar rats. J Med Sci. 2013;13:785-90. [DOI via Crossref]   
37. Ukwuani AN, Abukakar MG, Shehu RA, Hassan LG. Antiobesity effects of pulp extract Tamarindus indica in Albino rat. Asian J Biochem. 2008;3:221-7. [DOI via Crossref]   
38. Ibrahim E, Abbas SA. Chemical and biological evaluation of Tamarindus indica L. growing in Sudan. Acta Hortic. 1995;390:51-7. [DOI via Crossref]   
39. Coutino-Rodriguez R, Hernandez-Cruz P, Gillis-Rios H. Lectins in fruits having gastro-intestinal activity and their participation in the hemagglutinating property of Escherichia coli 0157. Arch Med Res. 2001;32:251-9. [Pubmed]   
40. Rasu N, Saleem B, Nawaz R. Preliminary screening of four common plants of family Caesalpiniacae. Pak J Pharm Sci. 1989;2:55-7.
41. Razali N, Mat-Junit S, Abdul-Muthalib AF, Subramaniam S, AbdulAziz A. Effects of various solvents on the extraction of antioxidant phenolics from the leaves, seeds, veins and skins of Tamarindus indica L. Food Chem. 2012;31:441-8. [DOI via Crossref]   
42. Gomathi R, Anusuya N, Chitravadivu C, Manian S. Antioxidant activity of lettuce tree (Pisonia morindifolia R.Br.) and tamarind tree (Tamarindus indica L) and their efficacy in peanut oil stability. Food Sci Biotechnol. 2011;20:1669-77. [DOI via Crossref]   
43. Bhadoriya SS, Ganeshpurkar A, Narwaria J, Rai G, Jain AP. Tamarindus indica: extent of explored potential, Pharmacogn Rev. 2011;5(9):73-81. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
44. Bravo L. Polyphenols: chemistry, dietary source, metabolism, and nutritional significance. Nutr Rev. 1998;56(11):317-33. [DOI via Crossref]    [Pubmed]   
45. Lim CY, Junit SM, Abdulla MA, Aziz AA. In vivo biochemical and gene expression analysis of the antioxidant activities and hypocholesterolemic properties of Tamarindus indica fruit pulp extract. PLoS One. 2013;8(7):e70058. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

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How to Cite this Article
Pubmed Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537


Web Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. https://www.njppp.com/?mno=181925 [Access: December 01, 2022]. doi:10.5455/njppp.2015.5.0903201537


AMA (American Medical Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537



Vancouver/ICMJE Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol. (2015), [cited December 01, 2022]; 5(4): 285-290. doi:10.5455/njppp.2015.5.0903201537



Harvard Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi (2015) Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. Natl J Physiol Pharm Pharmacol, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537



Turabian Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. 2015. Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537



Chicago Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. "Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 285-290. doi:10.5455/njppp.2015.5.0903201537



MLA (The Modern Language Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi. "Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 285-290. Print. doi:10.5455/njppp.2015.5.0903201537



APA (American Psychological Association) Style

E M Sutrisna, Devi Usdiana, Rizky Maidina Taqwin, Ahmad Roni Rosyidi (2015) Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 285-290. doi:10.5455/njppp.2015.5.0903201537