Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study

Hemalatha A; Pradeep Kumar B T; Vishnu Priya G; Latha Priya A; Vijaybabu K

doi:10.5455/njppp.2024.14.03122202429032024

2024, Vol: 14, Issue: 5

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Online Publishing Date:
05 / 04 / 2024

Natl J Physiol Pharm Pharmacol. 2024; 14(9):

doi: 10.5455/njppp.2024.14.03122202429032024

Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study

Hemalatha A, Pradeep Kumar B T, Vishnu Priya G, Latha Priya A, Vijaybabu K.

Abstract
Background: Breast cancer (BC) has become the most common cancer among women in India. Both amlodipine, belonging to calcium channel blockers, and nebivolol, belonging to the beta blockers class have proven anticancer mechanisms. However, the effect has not been compared between these drugs till now.

Aim and Objectives: The present study aims to compare the antiproliferation effects of amlodipine and nebivolol against human breast adenocarcinoma MCF-7 cells.

Materials and Methods: Cell viability assay was used to screen the antiproliferation effects of the study drug molecules in MCF-7 cell cultures. The IC50 values were derived graphically by plotting the cell viability against drug concentration.

Results: Both amlodipine and nebivolol exhibited dose-dependent cytotoxicity against BC cells. The IC50 of amlodipine was 166.6 μg/mL and nebivolol was 114.6 μg/mL.

Conclusion: In this study, nebivolol showed potent cytotoxicity compared to amlodipine. This inference may provide further insights into future drug research.

Key words: Breast Cancer Cells; Cell Viability Assay; Beta Receptors; Calcium Channels

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Pubmed Style

A H, T PKB, G VP, A LP, K V. Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. Natl J Physiol Pharm Pharmacol. Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

Web Style

A H, T PKB, G VP, A LP, K V. Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. https://www.njppp.com/?mno=193320 [Access: April 05, 2024]. doi:10.5455/njppp.2024.14.03122202429032024

AMA (American Medical Association) Style

A H, T PKB, G VP, A LP, K V. Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. Natl J Physiol Pharm Pharmacol. Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

Vancouver/ICMJE Style

A H, T PKB, G VP, A LP, K V. Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. Natl J Physiol Pharm Pharmacol, [cited April 05, 2024]; Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

Harvard Style

A, H., T, . P. K. B., G, . V. P., A, . L. P. & K, . V. (2024) Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. Natl J Physiol Pharm Pharmacol, Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

Turabian Style

A, Hemalatha, Pradeep Kumar B T, Vishnu Priya G, Latha Priya A, and Vijaybabu K. 2024. Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

Chicago Style

A, Hemalatha, Pradeep Kumar B T, Vishnu Priya G, Latha Priya A, and Vijaybabu K. "Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study." National Journal of Physiology, Pharmacy and Pharmacology Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

A, H., T, . P. K. B., G, . V. P., A, . L. P. & K, . V. (2024) Comparison of antiproliferative effects of amlodipine and nebivolol against MCF-7 cells: An in vitro study. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 05 Apr, 2024. doi:10.5455/njppp.2024.14.03122202429032024

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