E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research
Online Published: 31 Mar 2024
 


A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models

Salma Kamal S K, Kudagi B L, Pathapati Rama Mohan, Vurimi Bhopal Chandra, Manchi Haritha, Anjani Devi Nelavala.


Abstract
Background: Anxiety transcends a natural emotion, evolving into a pathological condition with the potential to trigger cascading cardiovascular and psychiatric disorders. Although conventional allopathic medicine offers treatment options, concerns regarding their side effects and long-term efficacy remain prevalent. Medicinal plants contain natural compounds that may be promising sources of therapeutic drugs.

Aims and Objectives: This study aims to compare the anxiolytic potential of ethanolic and aqueous extracts of Ocimum sanctum (OS). The growing appeal of plant-based therapies for anxiety stems from perceived advantages in safety and tolerability compared to synthetic drugs.

Materials and Methods: The anxiolytic activity of aqueous and ethanolic extract of OS is evaluated with an elevated plus maze test. A total of 36 Wistar albino rats (150–200 g) were used and randomly divided into six groups of six animals each. The effects of the test drug at different doses, 100 and 200 mg/kg, were compared with the standard anxiolytic drug diazepam at 2 mg/kg body weight and the control group using distilled water at 0.5 mL/kg body weight.

Results: The behavioral changes suggested reduced anxiety and openarm exploration in plus-maze indicates reduced anxiety in animals treated with OS extracts. The changes are significantly (P < 0.001) comparable with the standard drug diazepam.

Conclusion: The ethanolic extracts of OS are more significant than aqueous extracts for evaluating anti-anxiety activity in a dose-dependent manner. In addition, ethanolic extracts are more likely to contain a wider range of bioactive compounds, which are thought to be responsible for the anti-anxiety effects of OS.

Key words: Ocimum sanctum; Anti-Anxiety; Diazepam; Elevated Plus Maze Test; Ethanolic Extract; Aqueous Extract


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Salma Kamal S K
Articles by Kudagi B L
Articles by Pathapati Rama Mohan
Articles by Vurimi Bhopal Chandra
Articles by Manchi Haritha
Articles by Anjani Devi Nelavala
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

K SKS, L KB, Mohan PR, Chandra VB, Haritha M, Nelavala AD. A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. Natl J Physiol Pharm Pharmacol. 2024; 14(9): 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024

Web Style

K SKS, L KB, Mohan PR, Chandra VB, Haritha M, Nelavala AD. A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. https://www.njppp.com/?mno=194186 [Access: October 03, 2024]. doi:10.5455/njppp.2024.14.03120202419032024

AMA (American Medical Association) Style

K SKS, L KB, Mohan PR, Chandra VB, Haritha M, Nelavala AD. A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. Natl J Physiol Pharm Pharmacol. 2024; 14(9): 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024


Vancouver/ICMJE Style

K SKS, L KB, Mohan PR, Chandra VB, Haritha M, Nelavala AD. A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. Natl J Physiol Pharm Pharmacol. (2024), [cited October 03, 2024]; 14(9): 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024


Harvard Style

K, S. K. S., L, . K. B., Mohan, . P. R., Chandra, . V. B., Haritha, . M. & Nelavala, . A. D. (2024) A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. Natl J Physiol Pharm Pharmacol, 14 (9), 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024


Turabian Style

K, Salma Kamal S, Kudagi B L, Pathapati Rama Mohan, Vurimi Bhopal Chandra, Manchi Haritha, and Anjani Devi Nelavala. 2024. A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. National Journal of Physiology, Pharmacy and Pharmacology, 14 (9), 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024


Chicago Style

K, Salma Kamal S, Kudagi B L, Pathapati Rama Mohan, Vurimi Bhopal Chandra, Manchi Haritha, and Anjani Devi Nelavala. "A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024


MLA (The Modern Language Association) Style

K, Salma Kamal S, Kudagi B L, Pathapati Rama Mohan, Vurimi Bhopal Chandra, Manchi Haritha, and Anjani Devi Nelavala. "A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models." National Journal of Physiology, Pharmacy and Pharmacology 14.9 (2024), 1763-1766. Print. doi:10.5455/njppp.2024.14.03120202419032024


APA (American Psychological Association) Style

K, S. K. S., L, . K. B., Mohan, . P. R., Chandra, . V. B., Haritha, . M. & Nelavala, . A. D. (2024) A comparative study of anti-anxiety properties of ethanolic and aqueous extracts of Ocimum sanctum in animal models. National Journal of Physiology, Pharmacy and Pharmacology, 14 (9), 1763-1766. doi:10.5455/njppp.2024.14.03120202419032024




Most Viewed Articles
Most Accessed Articles

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract » doi: 10.5455/njppp.2013.3.109-114

    •
    Most Downloaded
    Top Downloaded Articles

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract » doi: 10.5455/njppp.2011.1.1-8

    •
    Most Cited Articles
    Most Cited Articles

    About National Journal of Physiology, Pharmacy and Pharmacology

      National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Eldaghayes Publisher

    www.eldagpublisher.com 

     
    All correspondence should be addressed to:
    Prof. Ibrahim Eldaghayes
    Editor-in-Chief
    National Journal of Physiology, Pharmacy and Pharmacology
    Email: ibrahim.eldaghayes@vetmed.edu.ly
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use