Abstract
Background: A number of studies have been carried out in India and worldwide reporting different incidence rates of surgical site infections (SSIs), various pathogens isolated, and their antibiotic sensitivity pattern. The difference incidence rates of SSIs may be due to differences in the hospital set-up, preventive measures taken and the prophylactic use of antibiotics. Even in the same hospital, the same type of survey at different periods may report different incidence rates of SSIs depending on prevailing conditions at the time of survey.

Aims and Objectives: To find out the current rate of incidence of SSI with common pathogen causing SSI and their susceptibility pattern in Sir Sayajirao General Hospital (SSGH), Vadodara.

Materials and Methods: This prospective study included 953 patients undergoing major operations in major surgical departments of Shri Sayajirao General Hospital, Vadodara over a period of 8-month.

Results: Out of 953 patients, 35 developed clinical signs and symptoms suggesting SSI (3.67%). Out of these 35 cases, no pathogen was isolated from 22 cases which may be due to subjective errors in collection and processing of samples. The predominant organisms isolated were Gram-negative organisms (84.6%), while Staphylococcus aureus-the only Gram-positive organism isolated contributed 15.4%. Imipenem, ampicillin+sulbactam, cefotaxime, and amikacin were the most sensitive antibiotic for Gram-negative organisms. Vancomycin, cloxacillin, oxacillin, and amoxicillinclavulanic acid combination were most sensitive antibiotic for Gram-positive organisms. Most of the commonly used antibiotics have got resistance for isolated organisms. Among them, the predominant is cefazolin, chloramphenicol, ofloxacin (OFX), erythromycin, roxithromycin and penicillin for Gram-positive organisms and netilmicin, tobramycin, piperacillin, OFX and gatifloxacin for Gram-negative organisms.

Conclusion: Regarding SSI, nowadays there is a trend toward comparative studies in the same hospital over years. In SSGH, Vadodara, there is a decrease in rate of incidence of SSI over years.

Key words: Surgical Site Infection; Antibiotic Sensitivity; Post-operative Complication