Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation

Rasha R Ahmed; Ayman M Mahmoud; Mohamed B Ashour; Amira M Kamel

doi:10.5455/njppp.2015.5.2907201567

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Original Research
Online Published: 23 Nov 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397

doi: 10.5455/njppp.2015.5.2907201567

Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation

Rasha R Ahmed, Ayman M Mahmoud, Mohamed B Ashour, Amira M Kamel.

Cited By:28

Abstract
Background: Kidney forms the main controlling organ in sustaining homeostasis and, thus, is vulnerable to toxicity by xenobiotics.

Aims and Objective: To evaluate the possible protective effects of the citrus flavonoid, hesperidin (HES), against diethylnitrosamine (DEN)-induced nephrotoxicity in rats.

Materials and Methods: Rats received a single intraperitoneal dose of DEN (200 mg/kg body weight). Two-weeks after DEN administration, rats received 0.5 g/L phenobarbital in drinking water for 12 weeks. HES (50, 100, and 200 mg/kg body weight) were orally administered from the first day of experiment.

Result: DEN administration induced nephrotoxicity evidenced or DEN-induced nephrotoxicity was evidenced by the histological alterations and significant increase in serum creatinine (P o 0.001), urea (P o 0.01), and uric acid (P o 0.001) levels. DEN-intoxicated rats exhibited a significant (P o 0.001) increase in renal lipid peroxidation levels and reduced glutathione content and activity of superoxide dismutase, glutathione peroxidase, and glutathione-Stransferase. Concomitant supplementation with all the doses of HES markedly prevented DEN-induced biochemical and histopathological alterations.

Conclusion: The study findings provide evidence that HES could protect against DEN-induced renal injury through abolishment of inflammation and oxidative stress and potentiation of the antioxidant defense system.

Key words: Flavonoids, Renal Injury, Oxidative Stress, Inflammation, Antioxidants

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Pubmed Style

Ahmed RR, Mahmoud AM, Ashour MB, Kamel AM. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397. doi:10.5455/njppp.2015.5.2907201567

Web Style

Ahmed RR, Mahmoud AM, Ashour MB, Kamel AM. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. https://www.njppp.com/?mno=197825 [Access: November 02, 2025]. doi:10.5455/njppp.2015.5.2907201567

AMA (American Medical Association) Style

Ahmed RR, Mahmoud AM, Ashour MB, Kamel AM. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. Natl J Physiol Pharm Pharmacol. 2015; 5(5): 391-397. doi:10.5455/njppp.2015.5.2907201567

Vancouver/ICMJE Style

Ahmed RR, Mahmoud AM, Ashour MB, Kamel AM. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. Natl J Physiol Pharm Pharmacol. (2015), [cited November 02, 2025]; 5(5): 391-397. doi:10.5455/njppp.2015.5.2907201567

Harvard Style

Ahmed, R. R., Mahmoud, . A. M., Ashour, . M. B. & Kamel, . A. M. (2015) Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. Natl J Physiol Pharm Pharmacol, 5 (5), 391-397. doi:10.5455/njppp.2015.5.2907201567

Turabian Style

Ahmed, Rasha R, Ayman M Mahmoud, Mohamed B Ashour, and Amira M Kamel. 2015. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 391-397. doi:10.5455/njppp.2015.5.2907201567

Chicago Style

Ahmed, Rasha R, Ayman M Mahmoud, Mohamed B Ashour, and Amira M Kamel. "Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 391-397. doi:10.5455/njppp.2015.5.2907201567

MLA (The Modern Language Association) Style

Ahmed, Rasha R, Ayman M Mahmoud, Mohamed B Ashour, and Amira M Kamel. "Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation." National Journal of Physiology, Pharmacy and Pharmacology 5.5 (2015), 391-397. Print. doi:10.5455/njppp.2015.5.2907201567

APA (American Psychological Association) Style

Ahmed, R. R., Mahmoud, . A. M., Ashour, . M. B. & Kamel, . A. M. (2015) Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5), 391-397. doi:10.5455/njppp.2015.5.2907201567

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