E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
30 / 05 / 2024

 


Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats

Laona Lal, Meera R Nath.


Abstract
Background: Curcuma amada rhizome is an indigenously used medicine to treat all kinds of prurigo, bronchitis, asthma, biliousness, diarrhea, hiccough, inflammations due to injuries, and lumbago.

Aims and Objectives: The objectives of the study are to assess the skeletal muscle relaxant activity of hydroalcoholic extract of C. amada rhizome in Wistar rats.

Materials and Methods: Extract was prepared according to the method of Rosenthaler using Soxhlet apparatus. Toxicity studies from previous literature had already proved the safety of the drug. The research was carried out following approval from the Institutional Animal Ethics Committee. The Wistar rats were orally administered with doses of 200, 400, and 800 mg/kg of the extract. The muscle relaxant action was assessed by rotarod method. Data analysis involved the use of paired t-test and one-way analysis of variance (ANOVA) through the Statistical Package for the Social Sciences software version 16.

Results: The fall off time was significantly reduced when administering extracts with doses of 200, 400, and 800 mg/kg (paired t-test, P < 0.001) compared to the control group, which consisted of the same animals before the administration of the test drug. The results when evaluated using ANOVA showed F = 16.203, P < 0.001. Dunnett’s test was utilized for post hoc analysis, revealing a notable change in muscle relaxation induced by the 200 mg/kg and 800 mg/kg doses of extract.

Conclusion: Findings of our study substantiate the use of C. amada rhizome for its skeletal muscle relaxant property in the treatment of various inflammatory conditions.

Key words: Curcuma amada; Muscle Relaxant; Rotarod; Soxhlet Apparatus; Wistar Rats


 
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How to Cite this Article
Pubmed Style

Lal L, Nath MR. Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. Natl J Physiol Pharm Pharmacol. Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024


Web Style

Lal L, Nath MR. Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. https://www.njppp.com/?mno=200245 [Access: June 02, 2024]. doi:10.5455/njppp.2024.14.05197202422052024


AMA (American Medical Association) Style

Lal L, Nath MR. Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. Natl J Physiol Pharm Pharmacol. Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024



Vancouver/ICMJE Style

Lal L, Nath MR. Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. Natl J Physiol Pharm Pharmacol, [cited June 02, 2024]; Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024



Harvard Style

Lal, L. & Nath, . M. R. (2024) Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. Natl J Physiol Pharm Pharmacol, Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024



Turabian Style

Lal, Laona, and Meera R Nath. 2024. Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024



Chicago Style

Lal, Laona, and Meera R Nath. "Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024



MLA (The Modern Language Association) Style

Lal, Laona, and Meera R Nath. "Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology Online First: 30 May, 2024. Web. 02 Jun 2024 doi:10.5455/njppp.2024.14.05197202422052024



APA (American Psychological Association) Style

Lal, L. & Nath, . M. R. (2024) Evaluation of skeletal muscle relaxant activity of hydroalcoholic extract of Curcuma amada rhizome in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, Online First: 30 May, 2024. doi:10.5455/njppp.2024.14.05197202422052024