E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research

Online Publishing Date:
27 / 02 / 2016

 


Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata

Vetriselvan Subramaniyan, Anil Middha.


Abstract
Background: Chronic alcohol consumption is a known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The present experimental model was evaluated with medicinal plant Boswellia serrata and the results reflected potential beneficial and reducing risk factors for liver disease.

Aims and Objectives: To determine the hepatoprotective activity of aqueous extract of Boswellia serrata. Chronic ethanol consumption is a major risk factor in determining liver disease and other metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism.

Materials and Methods: Male Wistar rats were divided into 6 groups (n = 6/group), and fed with a standard diet, ethanol, and ethanol supplemented with extracts for 6 weeks. The ethanol changes were determined via a serum enzyme profile of the liver. Liver toxicity was assessed in terms such as, serum indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, total proteins, albumin, globulin, albumin: globulin ratio, and liver weight.

Results: Oral administration of 250 and 500 mg/kg of AEBS offered a significant (P < 0.01) dose-dependent protection against ethanol-induced hepatotoxicity.

Conclusion: This study revealed that aqueous extract of Boswellia serrata in phytochemical constituents plays an active role against enzymes’ elevation and protection of liver.

Key words: Boswellia serrata; Ethanol; Serum Enzymes; Hepatotoxicity; Hepatoprotective


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Vetriselvan Subramaniyan
Articles by Anil Middha
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106

Web Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. https://www.njppp.com/?mno=211692 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.24122015106

AMA (American Medical Association) Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. 2016; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106


Vancouver/ICMJE Style

Vetriselvan Subramaniyan, Anil Middha. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol. (2016), [cited March 14, 2024]; 6(2): 170-174. doi:10.5455/njppp.2016.6.24122015106


Harvard Style

Vetriselvan Subramaniyan, Anil Middha (2016) Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. Natl J Physiol Pharm Pharmacol, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106


Turabian Style

Vetriselvan Subramaniyan, Anil Middha. 2016. Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106


Chicago Style

Vetriselvan Subramaniyan, Anil Middha. "Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 170-174. doi:10.5455/njppp.2016.6.24122015106


MLA (The Modern Language Association) Style

Vetriselvan Subramaniyan, Anil Middha. "Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata." National Journal of Physiology, Pharmacy and Pharmacology 6.2 (2016), 170-174. Print. doi:10.5455/njppp.2016.6.24122015106


APA (American Psychological Association) Style

Vetriselvan Subramaniyan, Anil Middha (2016) Chronic ethanol consumption–induced hepatotoxicity and protective effect of Boswellia serrata. National Journal of Physiology, Pharmacy and Pharmacology, 6 (2), 170-174. doi:10.5455/njppp.2016.6.24122015106


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

  National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Publisher

publishernjppp@gmail.com

 

Editorial query

editornjppp1@gmail.com

MOB - 8780040272