The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice

Ainun Naim; Mevy Trisna; Mhd Riza Marjoni

doi:10.5455/njppp.2018.8.0724024072018

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Original Research
Online Published: 30 Jul 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1446-1450

doi: 10.5455/njppp.2018.8.0724024072018

The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice

Ainun Naim, Mevy Trisna, Mhd Riza Marjoni.

Cited By:1

Abstract
Background: Traditional usage and many studies show that leaves salam and leaves bitter on a single use have an antidiabetic effect.

Aims and Objectives: The aim of this research is to know the combination of aqueous extract of salam leaves and bitter leaves in decreasing blood glucose level in white male mice-induced alloxan using pre-test and post-test group control design.

Materials and Methods: White male mice are grouped into six treatment groups: Normal control, negative controls (CMC-Na 0,5%), positive control (metformin HCl dose of 20 mg/KgBW), SB 7,5:20, SB 15:40, and SB 30:80. All groups except normal control-induced alloxan dose of 200 mg/KgBW on day-0, treatment continued from day 1day 24. The data obtained were blood glucose level of mice before and after treatment. Blood glucose level data were analyzed using ShapiroWilk test and continued by analysis of variance (ANOVA) with α = 0.01.

Results: The results showed that there was a decrease in blood glucose level a combination of aqueous extract salam leaves and bitter leaves at P <0.01.

Conclusion: Combination of aqueous extract salam leaves and bitter leaves is able to lower blood glucose level in male white mice.

Key words: Antidiabetic; Salam Leaves; Bitter Leaves; Aqueous Extract

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Pubmed Style

Naim A, Trisna M, Marjoni MR. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

Web Style

Naim A, Trisna M, Marjoni MR. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. https://www.njppp.com/?mno=2132 [Access: March 08, 2025]. doi:10.5455/njppp.2018.8.0724024072018

AMA (American Medical Association) Style

Naim A, Trisna M, Marjoni MR. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. 2018; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

Vancouver/ICMJE Style

Naim A, Trisna M, Marjoni MR. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol. (2018), [cited March 08, 2025]; 8(10): 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

Harvard Style

Naim, A., Trisna, . M. & Marjoni, . M. R. (2018) The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. Natl J Physiol Pharm Pharmacol, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

Turabian Style

Naim, Ainun, Mevy Trisna, and Mhd Riza Marjoni. 2018. The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

Chicago Style

Naim, Ainun, Mevy Trisna, and Mhd Riza Marjoni. "The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

MLA (The Modern Language Association) Style

Naim, Ainun, Mevy Trisna, and Mhd Riza Marjoni. "The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice." National Journal of Physiology, Pharmacy and Pharmacology 8.10 (2018), 1446-1450. Print. doi:10.5455/njppp.2018.8.0724024072018

APA (American Psychological Association) Style

Naim, A., Trisna, . M. & Marjoni, . M. R. (2018) The effect of antidiabetic combination of aqueous extracts of salam leaves (Stevia rebaudiana Bert.) and bitter leaves (Andrographis folium) in white male mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (10), 1446-1450. doi:10.5455/njppp.2018.8.0724024072018

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