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Original Research 


A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal.

Abstract
Background: Type 2 diabetes mellitus (DM) has a strong genetic component. Individuals of a parent with type 2 DM have an increased (40%) risk of diabetes. If both parents have type 2 DM, the risk approaches to 70%. Thus, this study was designed to evaluate cardiovascular parasympathetic functions in offsprings of type 2 diabetic parents.

Aims and Objectives: Study was done to compare and observe the degree of changes (if any) in the cardiovascular parasympathetic function tests in the offsprings of diabetic parents (cases) with offsprings of non-diabetic parents (controls) and provides timely lifestyle modifications to prevent the development of diabetes and its complications.

Materials and Methods: The cardiovascular parasympathetic function tests were carried out in 50 healthy offsprings of type 2 diabetic parents (study group) and 50 healthy offsprings of non-diabetic parents (control group) in the age range of 18-25 years randomly selected medical and para-medical students. Statistical analysis was done by unpaired Student’s t-test.

Results: Study shows decrease in all the three parasympathetic function tests (heart rate variability in response to deep breathing, heart rate variation in response to standing, and valsalva maneuver) in offsprings of type 2 diabetic parents (cases) as compared to non-diabetic parents (controls). However, the results were not statistically significant.

Conclusion: Our observations indicate that genetic factors in the form of altered genes could pass from diabetic parents to their offsprings and could manifest as altered response in parasympathetic function tests in healthy offsprings of diabetic parents even before the offsprings developing diabetes.

Key words: Parasympathetic Function Tests; Offsprings of Type 2 Diabetes Mellitus; Autonomic Neuropathy


 
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How to Cite this Article
Pubmed Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 364-367. doi:10.5455/njppp.2016.6.200220160428003


Web Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. https://www.njppp.com/?mno=215327 [Access: December 01, 2022]. doi:10.5455/njppp.2016.6.200220160428003


AMA (American Medical Association) Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 364-367. doi:10.5455/njppp.2016.6.200220160428003



Vancouver/ICMJE Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. Natl J Physiol Pharm Pharmacol. (2016), [cited December 01, 2022]; 6(5): 364-367. doi:10.5455/njppp.2016.6.200220160428003



Harvard Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal (2016) A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. Natl J Physiol Pharm Pharmacol, 6 (5), 364-367. doi:10.5455/njppp.2016.6.200220160428003



Turabian Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. 2016. A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 364-367. doi:10.5455/njppp.2016.6.200220160428003



Chicago Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. "A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 364-367. doi:10.5455/njppp.2016.6.200220160428003



MLA (The Modern Language Association) Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal. "A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents." National Journal of Physiology, Pharmacy and Pharmacology 6.5 (2016), 364-367. Print. doi:10.5455/njppp.2016.6.200220160428003



APA (American Psychological Association) Style

Charu Goel, Tanu Aggarwal, Syed Neyaz Hasan, Deepankar, Salman Shafi Siddiqui, Bhawana Sharma, Sudha Agarwal (2016) A case-control study of cardiovascular parasympathetic function tests in offsprings of type 2 diabetes mellitus parents. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 364-367. doi:10.5455/njppp.2016.6.200220160428003