E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 27 Dec 2024


Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels

Dr. Ancy A, Dr.hema S Nair, Dr.nisha V, Dr.jaimie T Jacob, Dr. Fathima S.


Abstract
BACKGROUND:
Pregnancy-associated plasma protein A (PAPP-A) is traditionally one of the combined biochemical screening methods for aneuploidies. Though PAPP-A has been found in many human organs, including the colon, kidneys, breast, and bone marrow, it is found more in pregnant woman's serum due to the production by syncytio-trophoblast of the placenta.Recent studies have explored on the use of PAPP-A for the prediction of adverse pregnancy outcomes.

AIM:
This study focusses on the obstetric outcomes in pregnant women with low PAPP-A levels.

METHODS:
This was a prospective cohort study conducted in the Department of Obstetrics & Gynaecology, SAT hospital, Trivandrum among antenatal women of gestational age 11 to 14 weeks. They were followed up to see the difference in pregnancy outcomes between women with low PAPP-A and normal PAPP-A levels.

RESULTS:
Women with low PAPP- A are at a significantly higher risk of complications as fetal growth restriction, preeclampsia, preterm birth, low birth weight and neonatal complications.

CONCLUSION:
The study supports the association between low PAPP-A levels and adverse obstetric outcomes.The findings underscore theimportance of identifying and closely monitoring pregnant women with low PAPP-A.Future research should focus on elucidating the underlying mechanisms linking low PAPP-A levels with adverse outcomes and exploring potential interventions to mitigate the risks associated with low PAPP-A levels.

Key words: Pregnant women, Pregnancy complications, Pregnancy-associated plasma protein A, Screening


 
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How to Cite this Article
Pubmed Style

A DA, Nair DS, V D, Jacob DT, S DF. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7


Web Style

A DA, Nair DS, V D, Jacob DT, S DF. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. https://www.njppp.com/?mno=226167 [Access: February 06, 2025]. doi:10.5455/NJPPP.2024.v14.i12.7


AMA (American Medical Association) Style

A DA, Nair DS, V D, Jacob DT, S DF. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7



Vancouver/ICMJE Style

A DA, Nair DS, V D, Jacob DT, S DF. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. Natl J Physiol Pharm Pharmacol. (2024), [cited February 06, 2025]; 14(12): 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7



Harvard Style

A, D. A., Nair, . D. S., V, . D., Jacob, . D. T. & S, . D. F. (2024) Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. Natl J Physiol Pharm Pharmacol, 14 (12), 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7



Turabian Style

A, Dr. Ancy, Dr.hema S Nair, Dr.nisha V, Dr.jaimie T Jacob, and Dr. Fathima S. 2024. Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7



Chicago Style

A, Dr. Ancy, Dr.hema S Nair, Dr.nisha V, Dr.jaimie T Jacob, and Dr. Fathima S. "Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7



MLA (The Modern Language Association) Style

A, Dr. Ancy, Dr.hema S Nair, Dr.nisha V, Dr.jaimie T Jacob, and Dr. Fathima S. "Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels." National Journal of Physiology, Pharmacy and Pharmacology 14.12 (2024), 2536-2542. Print. doi:10.5455/NJPPP.2024.v14.i12.7



APA (American Psychological Association) Style

A, D. A., Nair, . D. S., V, . D., Jacob, . D. T. & S, . D. F. (2024) Obstetric outcomes in pregnant women with low pregnancy-associated plasma protein-A (PAPP-A) levels. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2536-2542. doi:10.5455/NJPPP.2024.v14.i12.7