Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study

Atul Mallikarjun Kolhe; Anand Kale

doi:10.5455/njppp.2016.6.0616811072016

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Original Research
Online Published: 30 Jul 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(1): 32-37

doi: 10.5455/njppp.2016.6.0616811072016

Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study

Atul Mallikarjun Kolhe, Anand Kale.

Cited By:5

Abstract
Background: Various inflammatory mediators are involved in initiating and sustaining pain/inflammation cascade. Recently, leukotrienes (LTs) have been shown to be important mediators in pain and inflammation.

Aims and Objective: An experimental evaluation of analgesic, anti-inflammatory, and antipyretic activity of LT receptor antagonist-montelukast.

Materials and Methods: Wistar rats of either sex weighing 180-250 g and Swiss mice weighing 25-30 g were used. Analgesic activity of montelukast (20 mg/kg) was evaluated and compared with tramadol (10 mg/kg) and aspirin (300 mg/kg) using tail flick response method and acetic acid-induced writhing method. For evaluating anti-inflammatory activity, carrageenin-induced rat paw edema and formalin-induced arthritis models were used. The antipyretic activity was evaluated in Bakers yeast-induced pyrexia in rats.

Results: Montelukast (20 mg/kg) had significant analgesic activity compared to control in acetic acid-induced writhing model but was ineffective in tail flick model. Montelukast showed significant anti-inflammatory activity in carrageenin-induced paw edema and formalin-induced arthritis models. Montelukast did not show antipyretic activity.

Conclusion: Montelukast shows anti-inflammatory and analgesic activity which needs substantiation.

Key words: Montelukast; Tail Flick Method; Acetic Acid-induced Writhing

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Pubmed Style

Kolhe AM, Kale A. Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 32-37. doi:10.5455/njppp.2016.6.0616811072016

Web Style

Kolhe AM, Kale A. Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. https://www.njppp.com/?mno=233206 [Access: June 22, 2026]. doi:10.5455/njppp.2016.6.0616811072016

AMA (American Medical Association) Style

Kolhe AM, Kale A. Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 32-37. doi:10.5455/njppp.2016.6.0616811072016

Vancouver/ICMJE Style

Kolhe AM, Kale A. Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. Natl J Physiol Pharm Pharmacol. (2017), [cited June 22, 2026]; 7(1): 32-37. doi:10.5455/njppp.2016.6.0616811072016

Harvard Style

Kolhe, A. M. & Kale, . A. (2017) Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. Natl J Physiol Pharm Pharmacol, 7 (1), 32-37. doi:10.5455/njppp.2016.6.0616811072016

Turabian Style

Kolhe, Atul Mallikarjun, and Anand Kale. 2017. Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 32-37. doi:10.5455/njppp.2016.6.0616811072016

Chicago Style

Kolhe, Atul Mallikarjun, and Anand Kale. "Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 32-37. doi:10.5455/njppp.2016.6.0616811072016

MLA (The Modern Language Association) Style

Kolhe, Atul Mallikarjun, and Anand Kale. "Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study." National Journal of Physiology, Pharmacy and Pharmacology 7.1 (2017), 32-37. Print. doi:10.5455/njppp.2016.6.0616811072016

APA (American Psychological Association) Style

Kolhe, A. M. & Kale, . A. (2017) Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 32-37. doi:10.5455/njppp.2016.6.0616811072016

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