E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Motor nerve conduction parameters in patients with iron deficiency anemia

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham.

Abstract
Background: Worldwide, iron deficiency anemia (IDA) is the most common nutritional problem. Iron is very essential and has many important functions in brain energy metabolism, neurotransmitter function, and myelin formation. IDA may cause nerve dysfunctions.

Aims and Objectives: The purpose of the present study was to investigate the effects of IDA on peripheral motor nerve function.

Materials and Methods: A total of 40 individuals (25 females and 15 males) with IDA in the age range of 20-50 years from the Department of Medicine, SRM Medical College, as the study group and 30 participants (20 females and 10 males) without anemia as the control group were enrolled into this cross-sectional study. Patients with history of diabetes mellitus, neuromuscular, metabolic, vasculitic, or rheumatologic diseases and those taking medications that may alter central or peripheral nerve function were excluded from the study. The motor nerve conduction parameters, viz., distal latency, amplitude of compound muscle action potential (CMAP), and motor nerve conduction velocity (MNCV) were recorded bilaterally in median, ulnar, and posterior tibial nerves using standard protocols and settings. Values from patients were compared with those of controls by unpaired student’s t-test and one-way ANOVA.

Results: The observations revealed significantly prolonged distal motor latencies, reduced CMAP amplitudes, and slowed MNCV in the peripheral nerves in IDA.

Conclusion: The results indicated that the alteration in motor conduction parameters in IDA might be due to various functional and structural changes in peripheral nerves associated with iron deficiency.

Key words: Iron Deficiency Anemia; Motor Nerve Conduction; Peripheral Neuropathy


 
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REFERENCES
1. Rodak BF. Hematology: Clinical Principles and Applications. 3rd ed. Philadelphia, PA: Saunders; 2007. p. 220.
2. Yip R. Prevention and control of iron deficiency: Policy and strategy issues. J Nutr. 2002;132 4 Suppl:802S-5.
3. Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131(2S-2):568S-79.
4. Yehuda S. Neurochemical basis of behavioral effects of brain iron deficiency in animals. In: Dobbing J, editor. Brain, Behavior, and Iron in the Infant Diet. London: Springer-Verlag; 1990. p. 83-106.
5. Weinberg J, Dallman PR, Levine S. Iron deficiency during early development in the rat: Behavioral and physiological consequences. Pharmacol Biochem Behav. 1980;12(4):493-502. https://doi.org/10.1016/0091-3057(80)90179-3
6. Erikson KM, Jones BC, Hess EJ, Zhang Q, Beard JL. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav. 2001;69(3-4):409-18.
7. Larkin EC, Rao GA. Importance of fetal and neonatal iron: Adequacy for normal development of central nervous system. In: Dobbing J, editor. Brain, Behaviour, and Iron in the Infant Diet. London: Springer-Verlag; 1990. p. 43-63.
8. Rao R, Georgieff MK. Neonatal iron nutrition. Semin Neonatol. 2001;6(5):425-35. https://doi.org/10.1053/siny.2001.0063 [Pubmed]   
9. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization, (WHO/NMH/NHD/MNM/11.1); 2011.
10. Kimura J. Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice. 4th ed. New York: Oxford University Press; 2001.
11. Kabakus N, Ayar A, Yoldas TK, Ulvi H, Dogan Y, Yilmaz B, et al. Reversal of iron deficiency anemia-induced peripheral neuropathy by iron treatment in children with iron deficiency anemia. J Trop Pediatr. 2002;48(4):204-9. https://doi.org/10.1093/tropej/48.4.204 [Pubmed]   
12. Akyol A, Kiylioglu N, Kadikoylu G, Bolaman AZ, Ozgel N. Iron deficiency anemia and restless legs syndrome: Is there an electrophysiological abnormality? Clin Neurol Neurosurg. 2003;106(1):23-7. https://doi.org/10.1016/j.clineuro.2003.07.004 [Pubmed]   
13. Schwartz E. Iron deficiency anemia. In: Behrman RE, Kliegman MR, Arvin MA, editors. Textbook of Pediatrics. 15th ed. Philadelphia, PA: W.B Saunders; 1996. p. 1387-9.
14. Youdim MB. Neuropharmacological and neurobiochemical aspects of iron deficiency. In: Dobbing J, editor. Brain, Behaviour, and Iron in the Infant Diet. London: SpringerVerlag; 1990. p. 83-106.
15. Cook J. The nutritional assessment of iron status. Arch Latinoam Nutr. 1999;49 3 Suppl 2:11S-4.
16. Beard J. Iron deficiency alters brain development and functioning. J Nutr. 2003;133 5 Suppl 1:1468S-72.
17. El-Sebae AH, Soliman SA, Ahmed NS. Delayed neuropathy in sheep by the phosphonothioate insecticide cyanofenphos. J Environ Sci Health B. 1979;14(3):247-63. https://doi.org/10.1080/03601237909372126 [Pubmed]   
18. Brett EM. Vascular disorders of the nervous system in childhood. Paediatric Neurology. 3rd ed. New York: Churchill Livingstone; 1997. p. 579.
19. Ortiz E, Pasquini JM, Thompson K, Felt B, Butkus G,Beard J, et al. Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res. 2004;77(5):681-9. https://doi.org/10.1002/jnr.20207 [Pubmed]   
20. Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR. Oligodendrocytes and myelination: The role of iron. Glia. 2009;57(5):467-78. https://doi.org/10.1002/glia.20784 [Pubmed]   
21. Yu GS, Steinkirchner TM, Rao GA, Larkin EC. Effect of prenatal iron deficiency on myelination in rat pups. Am J Pathol. 1986;125(3):620-4.
22. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003;23:41-58. https://doi.org/10.1146/annurev.nutr.23.020102.075739 [Pubmed]   

How to Cite this Article
Pubmed Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. Motor nerve conduction parameters in patients with iron deficiency anemia. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 567-571. doi:10.5455/njppp.2016.6.0617103072016


Web Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. Motor nerve conduction parameters in patients with iron deficiency anemia. https://www.njppp.com/?mno=233885 [Access: December 02, 2022]. doi:10.5455/njppp.2016.6.0617103072016


AMA (American Medical Association) Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. Motor nerve conduction parameters in patients with iron deficiency anemia. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 567-571. doi:10.5455/njppp.2016.6.0617103072016



Vancouver/ICMJE Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. Motor nerve conduction parameters in patients with iron deficiency anemia. Natl J Physiol Pharm Pharmacol. (2016), [cited December 02, 2022]; 6(6): 567-571. doi:10.5455/njppp.2016.6.0617103072016



Harvard Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham (2016) Motor nerve conduction parameters in patients with iron deficiency anemia. Natl J Physiol Pharm Pharmacol, 6 (6), 567-571. doi:10.5455/njppp.2016.6.0617103072016



Turabian Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. 2016. Motor nerve conduction parameters in patients with iron deficiency anemia. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 567-571. doi:10.5455/njppp.2016.6.0617103072016



Chicago Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. "Motor nerve conduction parameters in patients with iron deficiency anemia." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 567-571. doi:10.5455/njppp.2016.6.0617103072016



MLA (The Modern Language Association) Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham. "Motor nerve conduction parameters in patients with iron deficiency anemia." National Journal of Physiology, Pharmacy and Pharmacology 6.6 (2016), 567-571. Print. doi:10.5455/njppp.2016.6.0617103072016



APA (American Psychological Association) Style

Anandhalakshmi Swaminathan, Subramaniyan Kumarasamy, Sundar Shanmugam, Saravanan Ayyavoo, Sundaravadivelu Velayutham (2016) Motor nerve conduction parameters in patients with iron deficiency anemia. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 567-571. doi:10.5455/njppp.2016.6.0617103072016