Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus

Anandhalakshmi Swaminathan; Kalaivani Amitkumar; Shivashekar Ganapathy; Saravanan Ayyavoo

doi:10.5455/njppp.2016.6.0719518072016

2026, Vol: 16, Issue: 1

16 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 01 Aug 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(1): 51-54

doi: 10.5455/njppp.2016.6.0719518072016

Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus

Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivashekar Ganapathy, Saravanan Ayyavoo.

Cited By:28

Abstract
Background: Diabetes mellitus (DM) is a global health problem with increased risk of vascular disease. Platelets may contribute to the development of vascular complications in subjects with diabetes. Larger platelets are more reactive than smaller ones; therefore, mean platelet volume (MPV) can be used as a marker for platelet activity.

Aim and Objectives: To compare the platelet parameters between diabetics and non-diabetics and to determine the effect of glycemic control and duration of diabetes on platelet parameters.

Materials and Methods: This cross-sectional study involved 100 Type-2 diabetic patients attending the Diabetology Outpatient Department of SRM Medical College Hospital and Research Centre aged between 30 and 60 years and 100 age-matched non-diabetic subjects as controls. Subjects with acute illness, those on antiplatelet medications and smokers were excluded. After history taking and clinical examination, glycosylated hemoglobin (HbA1c), fasting and postprandial blood glucose levels, platelet parameters such as platelet count, platelet distribution width (PDW), MPV, platelet-large cell ratio, and plateletcrit were determined.

Results: MPV was significantly increased among diabetics when compared to non-diabetics. MPV and PDW showed a significant increase in diabetics with HbA1c >7%, and MPV was increased in diabetics with >10 years duration of diabetes.

Conclusion: MPV was found to be higher in subjects with Type-2 diabetes and significantly increased in diabetics with poor glycemic control and having a longer duration of diabetes. MPV can be used as a prognostic marker of vascular complications in patients with DM.

Key words: Type-2 Diabetes Mellitus; Mean Platelet Volume; Glycosylated Hemoglobin

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Anandhalakshmi Swaminathan Articles by Kalaivani Amitkumar Articles by Shivashekar Ganapathy Articles by Saravanan Ayyavoo
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 51-54. doi:10.5455/njppp.2016.6.0719518072016

Web Style

Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. https://www.njppp.com/?mno=235384 [Access: June 23, 2026]. doi:10.5455/njppp.2016.6.0719518072016

AMA (American Medical Association) Style

Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 51-54. doi:10.5455/njppp.2016.6.0719518072016

Vancouver/ICMJE Style

Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. (2017), [cited June 23, 2026]; 7(1): 51-54. doi:10.5455/njppp.2016.6.0719518072016

Harvard Style

Swaminathan, A., Amitkumar, . K., Ganapathy, . S. & Ayyavoo, . S. (2017) Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol, 7 (1), 51-54. doi:10.5455/njppp.2016.6.0719518072016

Turabian Style

Swaminathan, Anandhalakshmi, Kalaivani Amitkumar, Shivashekar Ganapathy, and Saravanan Ayyavoo. 2017. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 51-54. doi:10.5455/njppp.2016.6.0719518072016

Chicago Style

Swaminathan, Anandhalakshmi, Kalaivani Amitkumar, Shivashekar Ganapathy, and Saravanan Ayyavoo. "Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 51-54. doi:10.5455/njppp.2016.6.0719518072016

MLA (The Modern Language Association) Style

Swaminathan, Anandhalakshmi, Kalaivani Amitkumar, Shivashekar Ganapathy, and Saravanan Ayyavoo. "Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus." National Journal of Physiology, Pharmacy and Pharmacology 7.1 (2017), 51-54. Print. doi:10.5455/njppp.2016.6.0719518072016

APA (American Psychological Association) Style

Swaminathan, A., Amitkumar, . K., Ganapathy, . S. & Ayyavoo, . S. (2017) Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 51-54. doi:10.5455/njppp.2016.6.0719518072016

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article