Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study

Debdipta Bose; Sushma Muraraiah; Hongali Chandrashekar

doi:10.5455/njppp.2017.7.0822216082016

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Original Research
Online Published: 05 Sep 2016

Natl J Physiol Pharm Pharmacol. 2017; 7(2): 183-188

doi: 10.5455/njppp.2017.7.0822216082016

Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study

Debdipta Bose, Sushma Muraraiah, Hongali Chandrashekar.

Cited By:4

Abstract
Background: Off-label drug prescribing is commonly seen all medical fields including psychiatry. A regular auditing and publishing of off-label drug prescribing is important as it provides strong scientific evidence for the clinicians on the effectiveness and acceptability of these proposed treatments.

Aims and Objective: To evaluate the pattern and predictors of off-label prescribing of antidepressants in psychiatry was taken up.

Materials and Methods: After obtaining the permission from Institutional Ethics Committee, an analytical cross-sectional study was conducted among patients attending psychiatry outpatient department for 6 months. Demographic and drug data were noted and analyzed for off-label drug use as per Food Drug Administration approved indication. Chi-square test and Students t-test were used to compare the off-label and approved indication groups. Multivariate binary logistic regression model was used to determine the predictors of offlabel prescribing.

Results: A total of 238 antidepressants were prescribed for 200 patients, of which 42.8% were used for off-label indication. Fluoxetine 44.1% and escitalopram 42.1% were the most frequently prescribed antidepressants in offlabel manner. The off label indications noted was somatoform disorder (12.5%), followed by generalized anxiety disorder (8.5%). There was significant causal association between off-label prescribing and number of antidepressant (odds ratio [OR] - 15.43, 95% confidence interval [CI] - 3.49-89.02, P < 0.05) and non-depressant use (OR - 74.37, 95% CI - 25.4-293.71, P ≤ 0.05).

Conclusion: Off-label use of antidepressants was 42.8% in this study. A number of antidepressants and non-depressant uses were the significant predictors of off-label prescribing in our hospital.

Key words: Antidepressant; Off-label Use; Non-depression Use; Psychiatry

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How to Cite this Article

Pubmed Style

Bose D, Muraraiah S, Chandrashekar H. Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 183-188. doi:10.5455/njppp.2017.7.0822216082016

Web Style

Bose D, Muraraiah S, Chandrashekar H. Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. https://www.njppp.com/?mno=238549 [Access: January 18, 2025]. doi:10.5455/njppp.2017.7.0822216082016

AMA (American Medical Association) Style

Bose D, Muraraiah S, Chandrashekar H. Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 183-188. doi:10.5455/njppp.2017.7.0822216082016

Vancouver/ICMJE Style

Bose D, Muraraiah S, Chandrashekar H. Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. Natl J Physiol Pharm Pharmacol. (2017), [cited January 18, 2025]; 7(2): 183-188. doi:10.5455/njppp.2017.7.0822216082016

Harvard Style

Bose, D., Muraraiah, . S. & Chandrashekar, . H. (2017) Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. Natl J Physiol Pharm Pharmacol, 7 (2), 183-188. doi:10.5455/njppp.2017.7.0822216082016

Turabian Style

Bose, Debdipta, Sushma Muraraiah, and Hongali Chandrashekar. 2017. Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 183-188. doi:10.5455/njppp.2017.7.0822216082016

Chicago Style

Bose, Debdipta, Sushma Muraraiah, and Hongali Chandrashekar. "Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 183-188. doi:10.5455/njppp.2017.7.0822216082016

MLA (The Modern Language Association) Style

Bose, Debdipta, Sushma Muraraiah, and Hongali Chandrashekar. "Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 7.2 (2017), 183-188. Print. doi:10.5455/njppp.2017.7.0822216082016

APA (American Psychological Association) Style

Bose, D., Muraraiah, . S. & Chandrashekar, . H. (2017) Evaluation of patterns and predictors of off-label prescribing of antidepressants in psychiatry at a tertiary care hospital - An analytical cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 183-188. doi:10.5455/njppp.2017.7.0822216082016

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