Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice

Kunjumon Dayana; Megaravalli R Manasa

doi:10.5455/njppp.2019.9.0100912012019

2025, Vol: 15, Issue: 6

15 / 6Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research
Online Published: 21 Jan 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(3): 231-234

doi: 10.5455/njppp.2019.9.0100912012019

Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice

Kunjumon Dayana, Megaravalli R Manasa.

Cited By:1

Abstract
Background: Medicinal plants have been the source of innumerable drugs. Opioids derived from plants are commonly used analgesics. However, they are associated with side effects ranging from vomiting, constipation to tolerance, and dependence. Hence, the search for safe and efficacious analgesic is on-going.

Aims and Objectives: The aim of the study was to assess the analgesic potential of the ethanolic extract of L. siceraria roots (EELSR) in albino mice by radiant heat method and to compare it with pentazocine.

Materials and Methods: Albino mice were divided into four groups randomly. Group 1 was given saline (0.1 mg/kg) orally (control). Group 2 was injected pentazocine 4 mg/kg (standard) intraperitoneally. Groups 3 and 4 were test groups and were administered EELSR 100 mg/kg BW and 200 mg/kg BW orally, respectively. Radiant heat method was used to screen for analgesic potential.

Results: Our study demonstrated the steady increase in reaction time in the test groups which received EELSR at both the doses. Maximum analgesic activity was observed at 60 min. EELSR has good analgesic activity in comparison with control. However, pentazocine has significantly better activity than EELSR at both the doses. EELSR at 200 mg/kg BW has comparable analgesic activity to pentazocine only at 15 min.

Conclusion: The EELSR has analgesic potential, but pentazocine is more potent analgesic than EELSR.

Key words: Lagenaria siceraria; Mice; Radiant Heat; Pentazocine; Analgesic

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Kunjumon Dayana Articles by Megaravalli R Manasa
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Dayana K, Manasa MR. Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 231-234. doi:10.5455/njppp.2019.9.0100912012019

Web Style

Dayana K, Manasa MR. Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. https://www.njppp.com/?mno=25267 [Access: November 02, 2025]. doi:10.5455/njppp.2019.9.0100912012019

AMA (American Medical Association) Style

Dayana K, Manasa MR. Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. Natl J Physiol Pharm Pharmacol. 2019; 9(3): 231-234. doi:10.5455/njppp.2019.9.0100912012019

Vancouver/ICMJE Style

Dayana K, Manasa MR. Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. Natl J Physiol Pharm Pharmacol. (2019), [cited November 02, 2025]; 9(3): 231-234. doi:10.5455/njppp.2019.9.0100912012019

Harvard Style

Dayana, K. & Manasa, . M. R. (2019) Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. Natl J Physiol Pharm Pharmacol, 9 (3), 231-234. doi:10.5455/njppp.2019.9.0100912012019

Turabian Style

Dayana, Kunjumon, and Megaravalli R Manasa. 2019. Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 231-234. doi:10.5455/njppp.2019.9.0100912012019

Chicago Style

Dayana, Kunjumon, and Megaravalli R Manasa. "Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 231-234. doi:10.5455/njppp.2019.9.0100912012019

MLA (The Modern Language Association) Style

Dayana, Kunjumon, and Megaravalli R Manasa. "Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice." National Journal of Physiology, Pharmacy and Pharmacology 9.3 (2019), 231-234. Print. doi:10.5455/njppp.2019.9.0100912012019

APA (American Psychological Association) Style

Dayana, K. & Manasa, . M. R. (2019) Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice. National Journal of Physiology, Pharmacy and Pharmacology, 9 (3), 231-234. doi:10.5455/njppp.2019.9.0100912012019

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article