Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome

Jayanthi C R; Ankita Bedwal; Kavitha Rajarathna

doi:10.5455/njppp.2017.7.1235625122016

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Original Research
Online Published: 11 Jan 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(5): 476-481

doi: 10.5455/njppp.2017.7.1235625122016

Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome

Jayanthi C R, Ankita Bedwal, Kavitha Rajarathna.

Cited By:6

Abstract
Background: Cutaneous adverse drug reactions (CADRs) are frequent manifestations of drug reactions that can lead to discontinuation of treatment, impaired quality of life and increased economic burden. Knowledge of drugs causing CADRs help in choosing safer drugs.

Aims and Objectives: To determine the clinical spectrum, causality, severity, and preventability of CADRs.

Materials and Methods: An observational study conducted from 2012 to 2016 to analyze the CADRs reported from Dermatology Department, of Bangalore Medical College and Research Institute to adverse drug reaction (ADR) Monitoring Center. Patients demographics, clinical and drug data, details of ADRs were collected as per CDSCO form. Causality, severity, and preventability were assessed using relevant scales.

Results: Out of 809 ADRs reported, 230 were CADRs. Male preponderance (56%) was seen. Age group of 21-40 years (57%) was most affected. Maximum CADRs were seen with beta-lactam class of drugs (20%), followed by nonsteroidal anti-inflammatory drugs (17.4%) and antiepileptics (13.5%). Maculopapular rash (26%) was the most common CADR. StevensJohnson syndrome (SJS) contributed to the majority of severe CADRs. Causative drug was withdrawn in 90% of cases. Causality assessment indicated 80.4% as probable and 19.6% as possible cases. 81% of CADRs were of moderate severity, and only 6% were severe like SJS. 11% were definitely preventable CADRs.

Conclusion: Wide clinical spectrum of CADRs was observed. Definitely preventable CADRs were due to improper recording of history of drug allergy and wrong choice of self-medication by the patients. Inconsistent with the previous literature, the incidence of diclofenac-induced SJS was found high.

Key words: Cutaneous Adverse Drug Reactions; Causality; Severity; Preventability

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Pubmed Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016

Web Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. https://www.njppp.com/?mno=253559 [Access: June 26, 2026]. doi:10.5455/njppp.2017.7.1235625122016

AMA (American Medical Association) Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. 2017; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016

Vancouver/ICMJE Style

R JC, Bedwal A, Rajarathna K. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol. (2017), [cited June 26, 2026]; 7(5): 476-481. doi:10.5455/njppp.2017.7.1235625122016

Harvard Style

R, J. C., Bedwal, . A. & Rajarathna, . K. (2017) Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. Natl J Physiol Pharm Pharmacol, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016

Turabian Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. 2017. Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016

Chicago Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. "Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 476-481. doi:10.5455/njppp.2017.7.1235625122016

MLA (The Modern Language Association) Style

R, Jayanthi C, Ankita Bedwal, and Kavitha Rajarathna. "Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome." National Journal of Physiology, Pharmacy and Pharmacology 7.5 (2017), 476-481. Print. doi:10.5455/njppp.2017.7.1235625122016

APA (American Psychological Association) Style

R, J. C., Bedwal, . A. & Rajarathna, . K. (2017) Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome. National Journal of Physiology, Pharmacy and Pharmacology, 7 (5), 476-481. doi:10.5455/njppp.2017.7.1235625122016

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