The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice

N Sistani Karampour; Ardeshir Arzi; Masumeh Rahimzadeh

doi:10.5455/njppp.2017.7.0936027102017

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Original Research
Online Published: 11 Nov 2017

Natl J Physiol Pharm Pharmacol. 2018; 8(2): 251-256

doi: 10.5455/njppp.2017.7.0936027102017

The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice

N Sistani Karampour, Ardeshir Arzi, Masumeh Rahimzadeh.

Cited By:5

Abstract
Background: Convulsion is one of the most important disorders of the central nervous system. On account of their lower side effects, the use of medical herbs for treating diseases, including convulsion, is on the rise.

Aims and Objectives: The present study aimed at investigating the effect of peppermint extract on pentylenetetrazol (PTZ)-induced convulsion in small white (laboratory) rats.

Materials and Methods: This study was conducted on 64 mice. The treatment groups received various (400, 600, and 800 mg/kg) doses of hydroalcoholic peppermint extract. The positive and negative control groups received Diazepam (1 mg/kg) and normal saline (10 ml/kg)30 min before intraperitoneal PTZ injection (85 mg/kg), respectively. Such factors as the onset, length, and severity of convulsion were then studied. To determine the best extract dose, the response times for min 15, 30, 45, and 60 before PTZ injection were studied.

Results: Results from the administration doses of the extract revealed that it had a dose-dependent effect in that no convulsion was seen at 800 mg/kg. To investigate the effect of interval between appropriate extract dose injection (800 mg/kg) on PTZ levels, 15-, 30-, 45-, and 60-min intervals were chosen. Results showed that the best result of the 800 mg/kg extract dose was achieved 30 min before PTZ injection where no convulsion was observed.

Conclusion: The overall result revealed that peppermint extract had preventive effects on PTZ-induced epileptic attacks in mice where the 800 mg/kg dose brought about the best result, i.e., no convulsion.

Key words: Peppermint; Pentylenetetrazol; Convulsion; Mice

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Pubmed Style

Karampour NS, Arzi A, Rahimzadeh M. The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. Natl J Physiol Pharm Pharmacol. 2018; 8(2): 251-256. doi:10.5455/njppp.2017.7.0936027102017

Web Style

Karampour NS, Arzi A, Rahimzadeh M. The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. https://www.njppp.com/?mno=278138 [Access: June 22, 2026]. doi:10.5455/njppp.2017.7.0936027102017

AMA (American Medical Association) Style

Karampour NS, Arzi A, Rahimzadeh M. The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. Natl J Physiol Pharm Pharmacol. 2018; 8(2): 251-256. doi:10.5455/njppp.2017.7.0936027102017

Vancouver/ICMJE Style

Karampour NS, Arzi A, Rahimzadeh M. The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. Natl J Physiol Pharm Pharmacol. (2018), [cited June 22, 2026]; 8(2): 251-256. doi:10.5455/njppp.2017.7.0936027102017

Harvard Style

Karampour, N. S., Arzi, . A. & Rahimzadeh, . M. (2018) The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. Natl J Physiol Pharm Pharmacol, 8 (2), 251-256. doi:10.5455/njppp.2017.7.0936027102017

Turabian Style

Karampour, N Sistani, Ardeshir Arzi, and Masumeh Rahimzadeh. 2018. The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (2), 251-256. doi:10.5455/njppp.2017.7.0936027102017

Chicago Style

Karampour, N Sistani, Ardeshir Arzi, and Masumeh Rahimzadeh. "The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 251-256. doi:10.5455/njppp.2017.7.0936027102017

MLA (The Modern Language Association) Style

Karampour, N Sistani, Ardeshir Arzi, and Masumeh Rahimzadeh. "The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice." National Journal of Physiology, Pharmacy and Pharmacology 8.2 (2018), 251-256. Print. doi:10.5455/njppp.2017.7.0936027102017

APA (American Psychological Association) Style

Karampour, N. S., Arzi, . A. & Rahimzadeh, . M. (2018) The effect of hydroalcoholic extract of Mentha piperita on pentylenetetrazol-induced convulsion in mice. National Journal of Physiology, Pharmacy and Pharmacology, 8 (2), 251-256. doi:10.5455/njppp.2017.7.0936027102017

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