Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease

Mohammad Amin Delavari; Ali Asghar Ravasi; Abbas Ali Gaeini; Reza Nouri

doi:10.5455/njppp.2018.8.1143710122017

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Original Research
Online Published: 09 Jan 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(4): 563-568

doi: 10.5455/njppp.2018.8.1143710122017

Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease

Mohammad Amin Delavari, Ali Asghar Ravasi, Abbas Ali Gaeini, Reza Nouri.

Cited By:1

Abstract
Background: Reviewing the previous studies reveals that the balance between stimulators and inhibitors of angiogenesis is of a great deal of importance. Among these factors, it can be pointed to the ANGPT2-like protein and the interferon (IFN)-beta. Since hypoxia is one of the most powerful stimulators of angiogenesis and considering the fact that endurance training creates a hypoxia condition.

Aims and Objectives: The purpose of the present study was to investigate the effects of 8 weeks of noncontinuous aerobic exercise on levels of angiopoietin2-like proteins and IFN beta (IFNβ) in male rats suffering from coronary artery disease. Materials and Methods: To this end, 32 months old rats weighting between 200 and 250 g were randomly selected. Afterward, 20 of the rats were made sick and further divided into two 10 member groups of control and experimental. The experimental group received 5 sessions of non-continuous aerobic exercises on animal per week for 8 weeks on an animal treadmill while the control group did not receive any exercises during these 8 weeks. After the period of the experiment, 5 mL of blood was taken from reach rats lower inferior vein 72 h after the past exercise after anesthetization by expert animal surgeons. Research data have been analyzed using the ANOVA test and the SPSS v.0.24 Software.

Results: Research findings indicate that after 8 weeks of participation in non-continuous aerobic exercises, a certain statistically significant difference was made between the control and experimental groups in terms of the level of IFNβ. However, no statistically significant difference was recorded for the level of angiopoitein-2 like proteins.

Conclusion: In general and with respect to the obtained results it can be stated that 8 weeks of non-continuous aerobic exercises did not result in an increase in the angiopoietin-2 like proteins level while resulting in a statistically significant decrease in the level of IFNβ.

Key words: Non-continuous Exercise; Angiogenesis; Coronary Arteries

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Pubmed Style

Delavari MA, Ravasi AA, Gaeini AA, Nouri R. Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. Natl J Physiol Pharm Pharmacol. 2018; 8(4): 563-568. doi:10.5455/njppp.2018.8.1143710122017

Web Style

Delavari MA, Ravasi AA, Gaeini AA, Nouri R. Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. https://www.njppp.com/?mno=283372 [Access: June 27, 2026]. doi:10.5455/njppp.2018.8.1143710122017

AMA (American Medical Association) Style

Delavari MA, Ravasi AA, Gaeini AA, Nouri R. Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. Natl J Physiol Pharm Pharmacol. 2018; 8(4): 563-568. doi:10.5455/njppp.2018.8.1143710122017

Vancouver/ICMJE Style

Delavari MA, Ravasi AA, Gaeini AA, Nouri R. Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. Natl J Physiol Pharm Pharmacol. (2018), [cited June 27, 2026]; 8(4): 563-568. doi:10.5455/njppp.2018.8.1143710122017

Harvard Style

Delavari, M. A., Ravasi, . A. A., Gaeini, . A. A. & Nouri, . R. (2018) Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. Natl J Physiol Pharm Pharmacol, 8 (4), 563-568. doi:10.5455/njppp.2018.8.1143710122017

Turabian Style

Delavari, Mohammad Amin, Ali Asghar Ravasi, Abbas Ali Gaeini, and Reza Nouri. 2018. Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. National Journal of Physiology, Pharmacy and Pharmacology, 8 (4), 563-568. doi:10.5455/njppp.2018.8.1143710122017

Chicago Style

Delavari, Mohammad Amin, Ali Asghar Ravasi, Abbas Ali Gaeini, and Reza Nouri. "Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 563-568. doi:10.5455/njppp.2018.8.1143710122017

MLA (The Modern Language Association) Style

Delavari, Mohammad Amin, Ali Asghar Ravasi, Abbas Ali Gaeini, and Reza Nouri. "Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease." National Journal of Physiology, Pharmacy and Pharmacology 8.4 (2018), 563-568. Print. doi:10.5455/njppp.2018.8.1143710122017

APA (American Psychological Association) Style

Delavari, M. A., Ravasi, . A. A., Gaeini, . A. A. & Nouri, . R. (2018) Investigating the effects eight weeks of non-continuous aerobic exercise on the levels of angiopoietin2-like protein and interferon beta in rats suffering from coronary artery disease. National Journal of Physiology, Pharmacy and Pharmacology, 8 (4), 563-568. doi:10.5455/njppp.2018.8.1143710122017

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