Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats

Saliha C K; Sandhya T Avadhany

doi:10.5455/njppp.2018.8.0413124042018

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Original Research
Online Published: 12 May 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(8): 1153-1157

doi: 10.5455/njppp.2018.8.0413124042018

Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats

Saliha C K, Sandhya T Avadhany.

Abstract
Background: Stress is considered as a risk factor for many diseases. It is mainly because stress can suppress the immune system in our body by different mechanisms and also progress the inflammatory reactions.

Aim and Objectives: In this study, we compared the immunomodulatory and anti-inflammatory effect of two commonly used spices: Curcumin and capsaicin.

Materials and Methods: Forty-two male albino rats were examined in this study. Rats were divided into seven groups as control, acute stress, chronic stress, acute stress, and chronic stress with curcumin and acute and chronic stress with capsaicin. Blood samples were collected and analyzed for the inflammatory and immunity markers.

Results: Results showed that exposure of chronic stress shows a significant change in CD4 and CD8 percentages and the selected inflammatory markers. Myeloperoxidase and C-reactive protein level increased significantly in the same group. Treatment with curcumin and capsaicin reverts the markers toward control group, but the change was not significant.

Conclusion: The results also show that there is no significant difference between the activity of curcumin and capsaicin. Acute stress showed immunomodulatory effects.

Key words: Stress; Immunity; Curcumin; Capsaicin; C-reactive Protein; Myeloperoxidase; CD4; CD8

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Pubmed Style

K SC, Avadhany ST. Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. Natl J Physiol Pharm Pharmacol. 2018; 8(8): 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

Web Style

K SC, Avadhany ST. Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. https://www.njppp.com/?mno=296893 [Access: January 17, 2025]. doi:10.5455/njppp.2018.8.0413124042018

AMA (American Medical Association) Style

K SC, Avadhany ST. Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. Natl J Physiol Pharm Pharmacol. 2018; 8(8): 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

Vancouver/ICMJE Style

K SC, Avadhany ST. Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. Natl J Physiol Pharm Pharmacol. (2018), [cited January 17, 2025]; 8(8): 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

Harvard Style

K, S. C. & Avadhany, . S. T. (2018) Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. Natl J Physiol Pharm Pharmacol, 8 (8), 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

Turabian Style

K, Saliha C, and Sandhya T Avadhany. 2018. Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 8 (8), 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

Chicago Style

K, Saliha C, and Sandhya T Avadhany. "Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

MLA (The Modern Language Association) Style

K, Saliha C, and Sandhya T Avadhany. "Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats." National Journal of Physiology, Pharmacy and Pharmacology 8.8 (2018), 1153-1157. Print. doi:10.5455/njppp.2018.8.0413124042018

APA (American Psychological Association) Style

K, S. C. & Avadhany, . S. T. (2018) Comparing the immunomodulatory and anti-inflammatory effect of curcumin and capsaicin on chronic stress-induced albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 8 (8), 1153-1157. doi:10.5455/njppp.2018.8.0413124042018

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