Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish

Glad Mohesh; Priyanka Pradeep; Rashmi K S; Semmal Syed Meerasa; Vetrivel Govindasamy

doi:10.5455/njppp.2022.12.02075202214022022

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Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1692-1697

doi: 10.5455/njppp.2022.12.02075202214022022

Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish

Glad Mohesh, Priyanka Pradeep, Rashmi K S, Semmal Syed Meerasa, Vetrivel Govindasamy.

Abstract
Background: Herbs used in medicinal practices by the indigenous healers are found to be of great importance in the management of diseases that are yet to have a cure by the available drugs. Practice of using herbs available in the vicinity by the locals as medication for ailments is a universal phenomenon. Dendropthoe falcata, an arboreal parasitic plant used in the indigenous medicine for the management of diabetes, is explored here for its acute hyperglycemic model adult zebrafishes.

Aim and Objectives: The aim of the study was to determine the hypoglycemic effect of the methanolic extract of Dendrophthoe falcata leaves in alloxan-induced acute diabetic adult zebrafish.

Materials and Methods: Adult zebrafishes were grouped into five groups with six fishes in each group exposing them to alloxan to induce acute hyperglycemia and then treating them with two test doses of 40 mg/dl and 60 mg/dl of the methanolic extract of the plant extract. Another group was treated with metformin with a dosage of 20 micro moles. Body mass index, blood glucose, and histopathological examination pre- and post-treatment for a period of 14 days were studied.

Results: The effect of the herbal extract in both the doses was promising when compared with the standard drug metformin; however, the cytoprotective effect was very predominant with the both doses of the extract. Acute hypoglycemic was comparatively good when compared with the standard group treated with metformin.

Conclusion: The antidiabetic effect of the arboreal parasitic plant has been established with a need for further exploration of this plant for a potential drug for diabetes mellitus.

Key words: Diabetes Mellitus; Dendropthoe falcata; Hypoglycemic Effect; Medicinal Herbs; Cytoprotective; Arboreal Parasite Plant

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How to Cite this Article

Pubmed Style

Mohesh G, Pradeep P, S RK, Meerasa SS, Govindasamy V. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

Web Style

Mohesh G, Pradeep P, S RK, Meerasa SS, Govindasamy V. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. https://www.njppp.com/?mno=30373 [Access: December 06, 2023]. doi:10.5455/njppp.2022.12.02075202214022022

AMA (American Medical Association) Style

Mohesh G, Pradeep P, S RK, Meerasa SS, Govindasamy V. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

Vancouver/ICMJE Style

Mohesh G, Pradeep P, S RK, Meerasa SS, Govindasamy V. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. Natl J Physiol Pharm Pharmacol. (2022), [cited December 06, 2023]; 12(10): 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

Harvard Style

Mohesh, G., Pradeep, . P., S, . R. K., Meerasa, . S. S. & Govindasamy, . V. (2022) Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. Natl J Physiol Pharm Pharmacol, 12 (10), 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

Turabian Style

Mohesh, Glad, Priyanka Pradeep, Rashmi K S, Semmal Syed Meerasa, and Vetrivel Govindasamy. 2022. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

Chicago Style

Mohesh, Glad, Priyanka Pradeep, Rashmi K S, Semmal Syed Meerasa, and Vetrivel Govindasamy. "Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

MLA (The Modern Language Association) Style

Mohesh, Glad, Priyanka Pradeep, Rashmi K S, Semmal Syed Meerasa, and Vetrivel Govindasamy. "Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish." National Journal of Physiology, Pharmacy and Pharmacology 12.10 (2022), 1692-1697. Print. doi:10.5455/njppp.2022.12.02075202214022022

APA (American Psychological Association) Style

Mohesh, G., Pradeep, . P., S, . R. K., Meerasa, . S. S. & Govindasamy, . V. (2022) Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1692-1697. doi:10.5455/njppp.2022.12.02075202214022022

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