E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats

Anandhalakshmi A, Madhav Rao C, Sarath Babu K.

Abstract
Background: Pain is the most common symptom in various pathological conditions requiring appropriate treatment with analgesics. Use of analgesics is limited by various adverse drug effects. The present study was aimed to evaluate the analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats.

Aim and Objective: The objective of this study is to evaluate the analgesic activity of hydroalcoholic extract of C. pictus leaves in Wistar albino rats.

Materials and Methods: The study was conducted on 30 Wistar albino rats and was divided into five groups each of six rats. Group-I (Sterile water-equivalent volume/po), Group-II Morphine (5 mg/kg/ip), Group-III CPHAE (200 mg/kg/po), Group-IV CPHAE (400 mg/kg/po), and Group-V Diclofenac (12.5 mg/kg/po). All the rats were administered respective drugs before starting of 30 min of experiment. Central analgesic (Tail clip and hot plate) and peripheral analgesic (Writhing test) methods were used to evaluate the analgesic activity. The data were recorded and analyzed with SPSS software.

Results: Group-II, III, IV and V showed significant analgesic activity compared to Group-I in both central and peripheral animal models. Group-II showed significant effect compared to Group-III and IV in the central analgesic activity. Group-V showed significant effect compared to Group-III and IV in peripheral analgesic activity. Group-IV showed significant effect compared to Group-III.

Conclusion: High dose of (400 mg/kg) C. pictus plant extract showed significant analgesic activity in the central and peripheral animal models compared to low dose.

Key words: Analgesic Activity; Costus pictus; Diclofenac; Hot Plate; Hydroalcoholic; Morphine; Tail Clip; Writhing Test


 
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How to Cite this Article
Pubmed Style

A A, C MR, K SB. Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022


Web Style

A A, C MR, K SB. Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. https://www.njppp.com/?mno=33153 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.05221202207062022


AMA (American Medical Association) Style

A A, C MR, K SB. Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022



Vancouver/ICMJE Style

A A, C MR, K SB. Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(7): 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022



Harvard Style

A, A., C, . M. R. & K, . S. B. (2022) Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. Natl J Physiol Pharm Pharmacol, 12 (7), 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022



Turabian Style

A, Anandhalakshmi, Madhav Rao C, and Sarath Babu K. 2022. Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022



Chicago Style

A, Anandhalakshmi, Madhav Rao C, and Sarath Babu K. "Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022



MLA (The Modern Language Association) Style

A, Anandhalakshmi, Madhav Rao C, and Sarath Babu K. "Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1079-1083. Print. doi:10.5455/njppp.2022.12.05221202207062022



APA (American Psychological Association) Style

A, A., C, . M. R. & K, . S. B. (2022) Preclinical evaluation of analgesic activity of hydroalcoholic extract of Costus pictus leaves in Wistar albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1079-1083. doi:10.5455/njppp.2022.12.05221202207062022