Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital

Jayant Rai; Shipra Kaushik; Himanshu Agrawal; Abhishek Mahajan; Preeti Yadav

doi:10.5455/njppp.2023.13.05215202217052022

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27 / 05 / 2022

Natl J Physiol Pharm Pharmacol. 2023; 13(1): 17-20

doi: 10.5455/njppp.2023.13.05215202217052022

Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital

Jayant Rai, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, Preeti Yadav.

Abstract
Background: Epilepsy is one of the common neurological disorders diagnosed early in life. Availability of many antiepileptic drugs (AEDs) makes it difficult to choose the appropriate pharmacotherapy.

Aim and Objective: Understanding the pattern of AED prescription to evaluate the rationality of AED prescriptions in epileptic patients.

Materials and Methods: This was a retrospective, observational study carried out at new civil hospital, Surat for a duration of 6 months. The study involved collecting data from the case files of all the patients irrespective of age or gender diagnosed with epilepsy and undergoing treatment from any of the outpatient departments of the hospital. Demographic details, clinical diagnosis, and detailed data about the prescribed pharmacotherapy were recorded in a pre-approved data sheet. The WHO prescribing indicators were evaluated for each prescription. Descriptive statistics was used.

Results: The average age of the patients was 21.64 ± 10.46 years. A total of 1565 drugs were prescribed in the 331 epilepsy patients’ prescriptions. Out of this, 551 drugs (35.21%) were antiepileptics. Most of the patients received monotherapy (75.53%). The most commonly prescribed drug was sodium valproate (46.10%) followed by phenytoin (30.13%) and carbamazepine (10%). The average AED per prescription was 1.70. Majority of the prescriptions (94.63%) used generic names. There were no injectable used and no fixed dose combinations were prescribed in any of the patients.

Conclusion: The prescriptions followed the rational prescribing pattern. Treatment of epilepsy is usually by monotherapy with valproate being the most commonly used AED. Prospective studies to evaluate adverse effects and patient compliance will help in efficient policy-making decisions.

Key words: Drug Utilization Study; Prescribing Indicators; Rational Use of Drugs

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How to Cite this Article

Pubmed Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022

Web Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. https://www.njppp.com/?mno=34147 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.05215202217052022

AMA (American Medical Association) Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022

Vancouver/ICMJE Style

Rai J, Kaushik S, Agrawal H, Mahajan A, Yadav P. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(1): 17-20. doi:10.5455/njppp.2023.13.05215202217052022

Harvard Style

Rai, J., Kaushik, . S., Agrawal, . H., Mahajan, . A. & Yadav, . P. (2023) Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022

Turabian Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. 2023. Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022

Chicago Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. "Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 17-20. doi:10.5455/njppp.2023.13.05215202217052022

MLA (The Modern Language Association) Style

Rai, Jayant, Shipra Kaushik, Himanshu Agrawal, Abhishek Mahajan, and Preeti Yadav. "Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13.1 (2023), 17-20. Print. doi:10.5455/njppp.2023.13.05215202217052022

APA (American Psychological Association) Style

Rai, J., Kaushik, . S., Agrawal, . H., Mahajan, . A. & Yadav, . P. (2023) Pattern of antiepileptic drug utilization in epilepsy patients in outpatient departments of a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (1), 17-20. doi:10.5455/njppp.2023.13.05215202217052022

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