Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease

Sareetha AV; Sridhar Prasad YP; Kiran T; Shashikumara

doi:10.5455/njppp.2021.11.123792020066012021

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Online Published: 19 Jan 2021

Natl J Physiol Pharm Pharmacol. 2021; 11(5): 495-499

doi: 10.5455/njppp.2021.11.123792020066012021

Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease

Sareetha Av, Sridhar Prasad Yp, Kiran T, Shashikumara.

Cited By:1

Abstract
Background: Woodfordia fruticosa (L.) Kurz. flowers belongs with the Lythraceae family and is known as Dhathaki in Ayurveda, which has been accounted for to have antimicrobial movement, cardioprotective action, antioxidant action, antiulcer action, immunomodulatory action, anti-fruitfulness action, and antitumor action in other in vitro contemplates.

Aims and Objectives: The current investigation is to explore the nootropic activity of the ethanolic extract of W. fruticosa (EWF) flowers scopolamine-induced mouse model of Alzheimers disease.

Materials and Methods: EWF was prepared by an incessant method using Soxhlet and cold evaporator equipment with respected temperature. EWF inside the doses 100 and 250 mg/kg frame weight become administrated to albino mice orally for 7 days accompanied through assessment for memory-enhancing interest using well-known protocols of the elevated plus maze (EPM) and Morris water maze (MWM).

Results: Repeated oral administration of EWF 100 and 250 mg/kg and standard Piracetam (100 mg/kg) for 7 days for Swiss albino mice with scopolamine-induced memory impairment. In the EPM and MWM test revealed that the repeated administration of EWF two different doses shown significant nootropic activity (P < 0.001), and the Piracetam confirmed a huge reduction in the both transfer and escape latency period.

Conclusion: EWF confirmed better learning and memory enhancement actions in animal models. The present study also concluded that the flowers are a rich source of phytoconstituents such as flavonoids, glycosides, and proteins, which may be recognized to its anti-amnesic activity.

Key words: Scopolamine; Woodfordia fruticosa Flowers; Elevated Plus Maze; Morris Water Maze

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Pubmed Style

Av S, Yp SP, T K, Shashikumara . Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. Natl J Physiol Pharm Pharmacol. 2021; 11(5): 495-499. doi:10.5455/njppp.2021.11.123792020066012021

Web Style

Av S, Yp SP, T K, Shashikumara . Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. https://www.njppp.com/?mno=35892 [Access: November 02, 2025]. doi:10.5455/njppp.2021.11.123792020066012021

AMA (American Medical Association) Style

Av S, Yp SP, T K, Shashikumara . Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. Natl J Physiol Pharm Pharmacol. 2021; 11(5): 495-499. doi:10.5455/njppp.2021.11.123792020066012021

Vancouver/ICMJE Style

Av S, Yp SP, T K, Shashikumara . Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. Natl J Physiol Pharm Pharmacol. (2021), [cited November 02, 2025]; 11(5): 495-499. doi:10.5455/njppp.2021.11.123792020066012021

Harvard Style

Av, S., Yp, . S. P., T, . K. & Shashikumara, . (2021) Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. Natl J Physiol Pharm Pharmacol, 11 (5), 495-499. doi:10.5455/njppp.2021.11.123792020066012021

Turabian Style

Av, Sareetha, Sridhar Prasad Yp, Kiran T, and Shashikumara. 2021. Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. National Journal of Physiology, Pharmacy and Pharmacology, 11 (5), 495-499. doi:10.5455/njppp.2021.11.123792020066012021

Chicago Style

Av, Sareetha, Sridhar Prasad Yp, Kiran T, and Shashikumara. "Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 495-499. doi:10.5455/njppp.2021.11.123792020066012021

MLA (The Modern Language Association) Style

Av, Sareetha, Sridhar Prasad Yp, Kiran T, and Shashikumara. "Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease." National Journal of Physiology, Pharmacy and Pharmacology 11.5 (2021), 495-499. Print. doi:10.5455/njppp.2021.11.123792020066012021

APA (American Psychological Association) Style

Av, S., Yp, . S. P., T, . K. & Shashikumara, . (2021) Nootropic activity of ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers on scopolamine-induced mouse model of Alzheimers disease. National Journal of Physiology, Pharmacy and Pharmacology, 11 (5), 495-499. doi:10.5455/njppp.2021.11.123792020066012021

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